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MLXIPL [nucleoplasm]
Stable Identifier
R-HSA-163683
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
ChREBP protein
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
AMPK inhibits chREBP transcriptional activation activity (Homo sapiens)
Phosphorylation of ChREBP at Serine 556 by AMPK (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
ChREBP activates metabolic gene expression (Homo sapiens)
Formation of ChREBP:MLX heterodimer (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX binds ACACA gene promoter (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX:ACACA gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX binds ACACB gene promoter (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX:ACACB gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX binds ACLY gene promoter (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX:ACLY gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX binds AGPAT1 gene promoter (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX: AGPAT1 gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX binds FASN gene promoter (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX:FASN gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX binds PKLR gene promoter (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
MLXIPL:MLX:PKLR gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
Transcriptional activation of ACACA by ChREBP:MLX (Homo sapiens)
MLXIPL:MLX:ACACA gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
Transcriptional activation of ACACB by ChREBP:MLX (Homo sapiens)
MLXIPL:MLX:ACACB gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
Transcriptional activation of AGPAT1 by ChREBP:MLX (Homo sapiens)
MLXIPL:MLX: AGPAT1 gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX (Homo sapiens)
MLXIPL:MLX:ACLY gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
Transcriptional activation of FASN monomer gene by ChREBP:MLX (Homo sapiens)
MLXIPL:MLX:FASN gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
Transcriptional activation of PKLR gene by ChREBP:MLX (Homo sapiens)
MLXIPL:MLX:PKLR gene [nucleoplasm] (Homo sapiens)
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
PKA-mediated phosphorylation of key metabolic factors (Homo sapiens)
Phosphorylation of ChREBP at Thr(653) by PKA (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)
Dephosphorylation of pChREBP (Ser 556) by PP2A (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)
MLXIPL [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NP71 MLXIPL
Gene Names
MLXIPL, BHLHD14, MIO, WBSCR14
Chain
chain:1-852
Reference Genes
BioGPS Gene:51085 MLXIPL
COSMIC (genes):MLXIPL MLXIPL
CTD Gene:51085 MLXIPL
dbSNP Gene:51085 MLXIPL
ENSEMBL:ENSG00000009950 MLXIPL
HGNC:12744 MLXIPL
KEGG:hsa:51085 MLXIPL
Monarch:51085 MLXIPL
NCBI Gene:51085 MLXIPL
OMIM:605678 MLXIPL
UCSC:Q9NP71 MLXIPL
Reference Transcript
RefSeq:NM_032952.2 MLXIPL
RefSeq:NM_032951.2 MLXIPL
RefSeq:NM_032954.2 MLXIPL
RefSeq:NM_032953.2 MLXIPL
Other Identifiers
11715307_s_at
11715308_s_at
11715309_s_at
11715310_s_at
17058524
221163_PM_s_at
221163_s_at
2963630
3056164
3056165
3056166
3056167
3056168
3056170
3056171
3056172
3056173
3056174
3056175
3056176
3056177
3056178
3056179
3056180
3056181
3056182
3056183
3056184
3056185
3056186
3056188
3056189
3056190
3056191
3056192
3056193
3056194
3056195
3056196
3056197
3056198
3056199
3056200
3056201
3939395
50234_r_at
51085
60082_s_at
8140085
A_23_P145786
A_24_P200831
A_24_P209389
GE58635
GO:0000122
GO:0000432
GO:0000785
GO:0000978
GO:0000981
GO:0001216
GO:0001227
GO:0001228
GO:0003677
GO:0003700
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0006629
GO:0008284
GO:0008610
GO:0009653
GO:0010255
GO:0033137
GO:0035538
GO:0042593
GO:0043226
GO:0045723
GO:0045821
GO:0045892
GO:0045893
GO:0045944
GO:0046889
GO:0046982
GO:0046983
GO:0055089
GO:0061629
GO:0070328
GO:0090324
GO:0097009
GO:0140110
GO:0140297
HMNXSV003053885
ILMN_1722073
ILMN_2399919
PH_hs_0014781
TC07001502.hg
g7705745_3p_a_at
Participates
as an input of
Phosphorylation of ChREBP at Thr(653) by PKA (Homo sapiens)
Phosphorylation of ChREBP at Serine 556 by AMPK (Homo sapiens)
Formation of ChREBP:MLX heterodimer (Homo sapiens)
as an output of
Dephosphorylation of pChREBP (Thr 666) by PP2A (Homo sapiens)
Dephosphorylation of pChREBP (Ser 556) by PP2A (Homo sapiens)
as a component of
MLXIPL:MLX [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T653-MLXIPL [cytosol]
p-S196,T653-MLXIPL [cytosol]
p-T653-MLXIPL [nucleoplasm]
p-S556-MLXIPL [nucleoplasm]
Inferred To
MLXIPL [nucleoplasm]
(Canis familiaris)
MLXIPL [nucleoplasm]
(Sus scrofa)
mml-1 [nucleoplasm]
(Caenorhabditis elegans)
Mlxipl [nucleoplasm]
(Rattus norvegicus)
Mondo [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_116571.1
,
NP_116570.1
,
NP_116572.1
,
NP_116569.1
ENSEMBL
ENST00000345114
,
ENST00000429400
,
ENST00000354613
,
ENST00000313375
,
ENST00000414749
,
ENSP00000412330
,
ENSP00000346629
,
ENSP00000320886
,
ENSP00000406296
,
ENSP00000343767
OpenTargets
ENSG00000009950
HPA
ENSG00000009950-MLXIPL
PRO
Q9NP71
Pharos - Targets
Q9NP71
GlyGen
Q9NP71
PDB
6YGJ
,
6MJL
,
8BTQ
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