Reactome | PLIN1 [lipid droplet]

PLIN1 [lipid droplet]

Stable Identifier

R-HSA-163460

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lipid droplet

Synonyms

perilipin, PLIN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
      - Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
        
        MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
        
        PLIN1 gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
        
        PLIN1 [lipid droplet] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60240 PLIN1

Gene Names

PLIN1, PERI, PLIN

Chain

chain:1-522

Reference Genes

BioGPS Gene:5346 PLIN1

COSMIC (genes):PLIN1 PLIN1

CTD Gene:5346 PLIN1

dbSNP Gene:5346 PLIN1

ENSEMBL:ENSG00000166819 PLIN1

HGNC:9076 PLIN1

Monarch:5346 PLIN1

NCBI Gene:5346 PLIN1

OMIM:170290 PLIN1

UCSC:O60240 PLIN1

Reference Transcript

Other Identifiers

11744311_a_at

11758374_s_at

11763833_at

16813173

205913_PM_at

205913_at

3638547

3638548

3638549

3638550

3638551

3638553

3638554

3638555

3638556

3638557

3638558

3638560

3638561

3638562

3638563

3638564

3638565

37122_at

5346

7991313

A_23_P26154

GE53123

GO:0005515

GO:0005783

GO:0005811

GO:0005829

GO:0006629

GO:0008289

GO:0016020

GO:0016042

GO:0043226

GO:0070417

HMNXSV003009710

ILMN_1665562

PH_hs_0031487

TC15001834.hg

g4505884_3p_at

Participates

as an output of

as a component of

perilipin:CGI-58 complex [lipid droplet] (Homo sapiens)

as an input of

perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP (Homo sapiens)

Other forms of this molecule

p-S81,S277-PLIN1 [lipid droplet]

Cross References

ENSEMBL

ENST00000430628, ENSP00000402167, ENSP00000300055, ENST00000300055

OpenTargets

ENSG00000166819

HPA

ENSG00000166819-PLIN1

PRO

O60240

Pharos - Targets

O60240

GlyGen

O60240

Orphanet

PLIN1

HMDB Protein

HMDBP02663

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14520 AQP7	1	AQP7 [plasma membrane] (R-HSA-381264)	0.571	4