Expression of PLIN1 regulated by NR1H2 or NR1H3

Stable Identifier
R-HSA-9608048
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of PLIN1 regulated by NR1H2 or NR1H3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The perilipin 1 (PLIN1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Liver X receptors (LXRα, NR1H2,3) up-regulate basal human adipocyte lipolysis partially through NR1H2,3 binding to the PLIN1 promoter and down-regulation of PLIN1 expression (Stenson BM et al. 2011). By selective knockdown of either NR1H2 or NR1H3, NR1H3 was found to be the major isoform mediating the lipolysis-related effects of NR1H2,3. The Reactome event of NR1H2,3-regulated expression of PLIN1 is inferred from the analogous event regulated by a synthetic NR1H2,3 agonist GW3965 (Stenson BM et al. 2011).
Literature References
PubMed ID Title Journal Year
21030586 Liver X receptor (LXR) regulates human adipocyte lipolysis

Arner, P, Langin, D, Blomqvist, L, Wang, V, Mairal, A, Laurencikiene, J, Stenson, BM, Jocken, JW, Dahlman, I, Pettersson, AM, Rydén, M, Venteclef, N, Aström, G, Clément, K

J. Biol. Chem. 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PLIN1 gene:NR1H2,3:RXR:NR1H2,3 ligand [nucleoplasm] (Homo sapiens)
Authored
Shamovsky, V  (2018-01-19)
Reviewed
D'Eustachio, P  (2018-12-29)
Repa, JJ  (2019-08-09)
Cummins, CL  (2019-08-09)
Created
Shamovsky, V  (2018-05-09)
Cite Us!