Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MMP8(21-467) [extracellular region]
Stable Identifier
R-HSA-1604708
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
proMMP8, Neutrophil collagenase, MMP8_HUMAN, MMP8
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of proMMP8 (Homo sapiens)
MMP8(21-467) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22894 MMP8
Gene Names
MMP8, CLG1
Chain
signal peptide:1-20, propeptide:21-100, chain:101-467
Reference Genes
BioGPS Gene:4317 MMP8
COSMIC (genes):MMP8 MMP8
CTD Gene:4317 MMP8
dbSNP Gene:4317 MMP8
ENSEMBL:ENSG00000118113 MMP8
HGNC:7175 MMP8
KEGG:hsa:4317 MMP8
Monarch:4317 MMP8
NCBI Gene:4317 MMP8
OMIM:120355 MMP8
UCSC:P22894 MMP8
Reference Transcript
RefSeq:NM_002424.2 MMP8
RefSeq:NM_001304441.1 MMP8
RefSeq:NM_001304442.1 MMP8
Other Identifiers
11729349_at
11729350_a_at
11729351_a_at
11748210_a_at
16743686
207329_PM_at
207329_at
231688_PM_at
231688_at
3388749
3388750
3388752
3388753
3388754
3388755
3388756
3388757
3388758
3388759
3388760
3388761
3388762
3388764
3388765
3388766
3388769
3388770
3388772
4317
681_at
7951246
A_23_P24493
GE477524
GE57532
GO:0003824
GO:0004175
GO:0004222
GO:0004252
GO:0005576
GO:0005615
GO:0006508
GO:0008233
GO:0008237
GO:0008270
GO:0016787
GO:0022617
GO:0030154
GO:0030198
GO:0030312
GO:0030574
GO:0031012
GO:0032760
GO:0035580
GO:0035987
GO:0043120
GO:0046872
GO:0062023
GO:0071222
GO:0140096
GO:0150078
GO:1903265
GO:1903980
GO:1904724
HMNXSV003012409
Hs.255877.0.A1_3p_at
ILMN_1736026
J05556_at
PH_hs_0024515
TC11002231.hg
g4505220_3p_at
Participates
as an input of
Activation of proMMP8 (Homo sapiens)
Other forms of this molecule
MMP8 [extracellular region]
MMP8 [specific granule lumen]
MMP8 [tertiary granule lumen]
Inferred To
MMP8(21-467) [extracellular region]
(Bos taurus)
MMP8(21-467) [extracellular region]
(Caenorhabditis elegans)
MMP8(21-467) [extracellular region]
(Canis familiaris)
MMP8(21-467) [extracellular region]
(Drosophila melanogaster)
MMP8(21-467) [extracellular region]
(Gallus gallus)
MMP8(21-467) [extracellular region]
(Mus musculus)
MMP8(21-467) [extracellular region]
(Rattus norvegicus)
MMP8(21-467) [extracellular region]
(Sus scrofa)
MMP8(21-467) [extracellular region]
(Xenopus tropicalis)
Homologues of MMP8(21-467) [extracellular region]
(Caenorhabditis elegans)
Homologues of MMP8(21-467) [extracellular region]
(Drosophila melanogaster)
Homologues of MMP8(21-467) [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001291371.1
,
NP_002415.1
,
NP_001291370.1
ZINC - World Drugs
MMP8_HUMAN
Guide to Pharmacology - Targets
1632
OpenTargets
ENSG00000118113
ENSEMBL
ENST00000236826
,
ENSP00000236826
ZINC - Substances
MMP8_HUMAN
ZINC - Biogenic
MMP8_HUMAN
ZINC target
P22894
PRO
P22894
GlyGen
P22894
PDB
1ZP5
,
3DPE
,
1JAP
,
1BZS
,
1A86
,
1JAQ
,
1A85
,
1JJ9
,
3DPF
,
1KBC
,
1ZS0
,
1MMB
,
1ZVX
,
1I73
,
4QKZ
,
2OY2
,
1I76
,
5H8X
,
2OY4
,
1JH1
,
3TT4
,
1JAN
,
1JAO
,
3DNG
,
1MNC
ZINC - Investigational
MMP8_HUMAN
ZINC - Metabolites
MMP8_HUMAN
IntEnz
3.4.24.34
HPA
ENSG00000118113-MMP8
Pharos - Targets
P22894
ZINC - Predictions - Purchasable
MMP8_HUMAN
HMDB Protein
HMDBP07814
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text