Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
MMP8 [extracellular region]
Stable Identifier
R-HSA-1442475
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Neutrophil collagenase, MMP8_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of proMMP8 (Homo sapiens)
MMP8 [extracellular region] (Homo sapiens)
Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Homo sapiens)
MMP1, 2, 3, 7,8,10,13,19 [extracellular region] (Homo sapiens)
MMP8 [extracellular region] (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type I degradation by MMP1,2,8,13, PRSS2 (Homo sapiens)
MMP1,2,8,13, PRSS2 [extracellular region] (Homo sapiens)
MMP8 [extracellular region] (Homo sapiens)
Collagen type II degradation by MMP1,3,8,13,PRSS2 (Homo sapiens)
MMP1,3,8,13, PRSS2 [extracellular region] (Homo sapiens)
MMP8 [extracellular region] (Homo sapiens)
Collagen type III degradation by MMP1,8,9,13 (Homo sapiens)
MMP1,8,9,13 [extracellular region] (Homo sapiens)
MMP8 [extracellular region] (Homo sapiens)
Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)
MMP1-3, 7-9, 12, 13 [extracellular region] (Homo sapiens)
MMP8 [extracellular region] (Homo sapiens)
MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Homo sapiens)
Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP8 [extracellular region] (Homo sapiens)
MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP8 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule lumen proteins (Homo sapiens)
Specific granule lumen proteins [extracellular region] (Homo sapiens)
MMP8 [extracellular region] (Homo sapiens)
Exocytosis of tertiary granule lumen proteins (Homo sapiens)
Tertiary granule lumen proteins [extracellular region] (Homo sapiens)
MMP8 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22894 MMP8
Gene Names
MMP8, CLG1
Chain
signal peptide:1-20, propeptide:21-100, chain:101-467
Reference Genes
BioGPS Gene:4317 MMP8
COSMIC (genes):MMP8 MMP8
CTD Gene:4317 MMP8
dbSNP Gene:4317 MMP8
ENSEMBL:ENSG00000118113 MMP8
ENSEMBL_homo_sapiens_GENE:ENSG00000118113 MMP8
HGNC:7175 MMP8
KEGG Gene (Homo sapiens):4317 MMP8
Monarch:4317 MMP8
NCBI Gene:4317 MMP8
OMIM:120355 MMP8
UCSC:P22894 MMP8
Reference Transcript
RefSeq:NM_001304441.1 MMP8
RefSeq:NM_002424.2 MMP8
RefSeq:NM_001304442.1 MMP8
Other Identifiers
0002810731
11729349_at
11729350_a_at
11729351_a_at
11748210_a_at
16743686
1A85
1A86
1BZS
1I73
1I76
1JAN
1JAO
1JAP
1JAQ
1JH1
1JJ9
1KBC
1MMB
1MNC
1ZP5
1ZS0
1ZVX
207329_at
21221
22935
231688_at
2OY2
2OY4
3388750
3388752
3388753
3388754
3388755
3388756
3388757
3388758
3388759
3388760
3388761
3388762
3388769
3388770
3DNG
3DPE
3DPF
3TT4
4317
4QKZ
5H8X
681_at
7951246
A_23_P24493
AAA88021
AAH74988
AAH74989
AAZ38714
CCDS8320
E9PIY7
E9PJB3
E9PL87
ENSG00000118113
ENSP00000236826
ENST00000236826
EntrezGene:4317
g4505220_3p_at
GE477524
GE57532
GO:0001774
GO:0002376
GO:0003674
GO:0004222
GO:0004252
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005737
GO:0006508
GO:0006810
GO:0008150
GO:0008233
GO:0008237
GO:0008270
GO:0009056
GO:0009058
GO:0009790
GO:0010628
GO:0010629
GO:0016192
GO:0016787
GO:0022617
GO:0030154
GO:0030198
GO:0030574
GO:0031012
GO:0031410
GO:0032693
GO:0032755
GO:0032760
GO:0034641
GO:0035580
GO:0035987
GO:0043167
GO:0043226
GO:0043312
GO:0045429
GO:0046872
GO:0048646
GO:0048856
GO:0062023
GO:0150077
GO:0150078
GO:1904724
HGNC:7175
HPA021221
HPA022935
Hs.255877.0.A1_3p_at
ILMN_1736026
IPR000585
IPR001818
IPR002477
IPR006026
IPR018486
IPR018487
IPR021158
IPR021190
IPR024079
IPR028709
IPR033739
IPR036365
IPR036366
IPR036375
J05556_at
MIM:120355
MMP8
MMP8-201
NM_001304441
NM_001304442
NM_002424
NP_001291370
NP_001291371
NP_002415
PF00045
PF00413
PF01471
PH_hs_0024515
PR00138
SM00120
SM00235
TC11002231.hg
uc001phe.2
UPI00000422BB
XM_011542834
XM_011542835
XM_017017771
XP_011541136
XP_011541137
XP_016873260
Participant Of
hasCandidate
MMP1, 3, 13, (2, 7-12, 19) [extracellular region]
hasMember
MMP1, 2, 3, 7,8,10,13,19 [extracellular region]
MMP1,2,8,13, PRSS2 [extracellular region]
MMP1,3,8,13, PRSS2 [extracellular region]
MMP1,8,9,13 [extracellular region]
MMP1-3, 7-9, 12, 13 [extracellular region]
Specific granule lumen proteins [extracellular region]
Tertiary granule lumen proteins [extracellular region]
output
Activation of proMMP8
Other forms of this molecule
MMP8(21-467) [extracellular region]
MMP8 [tertiary granule lumen]
MMP8 [specific granule lumen]
Inferred To
MMP8 [extracellular region] (Arabidopsis thaliana)
MMP8 [extracellular region] (Bos taurus)
MMP8 [extracellular region] (Canis familiaris)
MMP8 [extracellular region] (Drosophila melanogaster)
MMP8 [extracellular region] (Gallus gallus)
MMP8 [extracellular region] (Mus musculus)
MMP8 [extracellular region] (Oryza sativa)
MMP8 [extracellular region] (Rattus norvegicus)
MMP8 [extracellular region] (Sus scrofa)
MMP8 [extracellular region] (Taeniopygia guttata)
MMP8 [extracellular region] (Xenopus tropicalis)
Homologues of MMP8 [extracellular region] (Arabidopsis thaliana)
Homologues of MMP8 [extracellular region] (Oryza sativa)
Homologues of MMP8 [extracellular region] (Sus scrofa)
Homologues of MMP8 [extracellular region] (Xenopus tropicalis)
Cross References
RefSeq
NP_001291371.1
,
NP_001291370.1
,
NP_002415.1
ZINC - World Drugs
MMP8_HUMAN
OpenTargets
ENSG00000118113
ZINC - Substances
MMP8_HUMAN
ZINC - Biogenic
MMP8_HUMAN
ZINC target
P22894
PRO
P22894
PDB
1JAQ
,
1JH1
,
1MMB
,
1I73
,
3DNG
,
4QKZ
,
1JJ9
,
1JAO
,
1ZP5
,
1A85
,
2OY4
,
1JAP
,
1KBC
,
1A86
,
1JAN
,
1MNC
,
2OY2
,
1ZS0
,
1I76
,
3DPE
,
3DPF
,
1BZS
,
3TT4
,
1ZVX
,
5H8X
ZINC - Metabolites
MMP8_HUMAN
GeneCards
P22894
DOCK Blaster
4QKZ
,
1MMB
,
3DPE
,
1ZVX
,
3DPF
,
1ZS0
,
2OY4
,
1ZP5
,
5H8X
,
1I73
,
3TT4
,
1I76
,
1JJ9
,
2OY2
,
1JAP
,
1JAQ
,
1JAN
,
1JAO
,
1KBC
,
1A85
,
1A86
,
1JH1
,
1BZS
,
3DNG
,
1MNC
BRENDA (Homo sapiens)
3.4.24.34
ZINC - Predictions - Purchasable
MMP8_HUMAN
HMDB Protein
HMDBP07814
© 2019
Reactome