Reactome | MMP8 [extracellular region]

MMP8 [extracellular region]

Stable Identifier

R-HSA-1442475

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Neutrophil collagenase, MMP8_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P22894 MMP8

Gene Names

MMP8, CLG1

Chain

signal peptide:1-20, propeptide:21-100, chain:101-467

Reference Genes

BioGPS Gene:4317 MMP8

COSMIC (genes):MMP8 MMP8

CTD Gene:4317 MMP8

dbSNP Gene:4317 MMP8

ENSEMBL:ENSG00000118113 MMP8

HGNC:7175 MMP8

KEGG Gene (Homo sapiens):4317 MMP8

Monarch:4317 MMP8

NCBI Gene:4317 MMP8

OMIM:120355 MMP8

UCSC:P22894 MMP8

Reference Transcript

Other Identifiers

0002810731

11729349_at

11729350_a_at

11729351_a_at

11748210_a_at

16743686

207329_at

231688_at

3388749

3388750

3388752

3388753

3388754

3388755

3388756

3388757

3388758

3388759

3388760

3388761

3388762

3388769

3388770

4317

681_at

7951246

A_23_P24493

GE477524

GE57532

GO:0002376

GO:0003674

GO:0004175

GO:0004222

GO:0004252

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0006464

GO:0006508

GO:0006810

GO:0006950

GO:0007165

GO:0008150

GO:0008233

GO:0008237

GO:0008270

GO:0009056

GO:0009058

GO:0009790

GO:0010628

GO:0010629

GO:0016192

GO:0016787

GO:0022617

GO:0030154

GO:0030198

GO:0030574

GO:0031012

GO:0031410

GO:0032693

GO:0032755

GO:0032760

GO:0034641

GO:0035580

GO:0035987

GO:0043167

GO:0043226

GO:0043312

GO:0043388

GO:0043410

GO:0045429

GO:0046330

GO:0046872

GO:0048646

GO:0048856

GO:0062023

GO:0150077

GO:0150078

GO:1901224

GO:1903428

GO:1903978

GO:1903980

GO:1904724

HMNXSV003012409

Hs.255877.0.A1_3p_at

ILMN_1736026

J05556_at

PH_hs_0024515

TC11002231.hg

g4505220_3p_at

Participates

as a member of

as a candidate of

MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)

as an output of

Activation of proMMP8 (Homo sapiens)

Other forms of this molecule

MMP8(21-467) [extracellular region]

MMP8 [specific granule lumen]

MMP8 [tertiary granule lumen]

Inferred To

Mmp2 [extracellular region] (Drosophila melanogaster)

Mmp8 [extracellular region] (Mus musculus)

Mmp8 [extracellular region] (Rattus norvegicus)

mmp13b [extracellular region] (Danio rerio)

MMP1 [extracellular region] (Gallus gallus)

zmp-6 [extracellular region] (Caenorhabditis elegans)

mmp13l [extracellular region] (Xenopus tropicalis)

zmp-2 [extracellular region] (Caenorhabditis elegans)

zmp-5 [extracellular region] (Caenorhabditis elegans)

Homologues of MMP8 [extracellular region] (Caenorhabditis elegans)

Homologues of MMP8 [extracellular region] (Drosophila melanogaster)

Homologues of MMP8 [extracellular region] (Xenopus tropicalis)

zmp-3 [extracellular region] (Caenorhabditis elegans)

zmp-4 [extracellular region] (Caenorhabditis elegans)

MMP8 [extracellular region] (Bos taurus)

MMP8 [extracellular region] (Caenorhabditis elegans)

MMP8 [extracellular region] (Canis familiaris)

MMP8 [extracellular region] (Sus scrofa)

MMP8 [extracellular region] (Xenopus tropicalis)

Mmp1 [extracellular region] (Drosophila melanogaster)

mmp13 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001291371.1, NP_002415.1, NP_001291370.1

ZINC - World Drugs

MMP8_HUMAN

Guide to Pharmacology - Targets

1632

OpenTargets

ENSG00000118113

ZINC - Substances

MMP8_HUMAN

ZINC target

P22894

ZINC - Biogenic

MMP8_HUMAN

PRO

P22894

GlyGen

P22894

PDB

1ZP5, 1MNC, 2OY2, 1KBC, 1JAN, 1JH1, 1JAP, 2OY4, 1JAO, 1JJ9, 3DNG, 1ZS0, 1A85, 1I73, 1MMB, 5H8X, 1JAQ, 1ZVX, 3TT4, 3DPF, 1BZS, 4QKZ, 1A86, 1I76, 3DPE

ZINC - Investigational

MMP8_HUMAN

ZINC - Metabolites

MMP8_HUMAN

IntEnz

3.4.24.34

GeneCards

P22894

HPA

ENSG00000118113-MMP8

Ensembl

ENST00000236826, ENSP00000236826, ENSG00000118113

Pharos - Targets

P22894

ZINC - Predictions - Purchasable

MMP8_HUMAN

HMDB Protein

HMDBP07814

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