Activation of proMMP8

Stable Identifier
R-HSA-1592398
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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proMMP8 is activated by tissue kallikrein, leukocyte elastase, trypsin and cathepsin G (Capodici et al. 1989, Knauper et al. 1990) probably at the predicted bait region, residues 30-36.

Literature References
PubMed ID Title Journal Year
2546891 Activation of neutrophil collagenase by cathepsin G

Capodici, C, Muthukumaran, G, Amoruso, MA, Berg, RA

Inflammation 1989
2159879 Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms

Knäuper, V, Krämer, S, Reinke, H, Tschesche, H

Eur J Biochem 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of proMMP8 initial activators [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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