Activation of proMMP8

Stable Identifier
R-HSA-1592398
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Activation of proMMP8
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proMMP8 is activated by tissue kallikrein, leukocyte elastase, trypsin and cathepsin G (Capodici et al. 1989, Knauper et al. 1990) probably at the predicted bait region, residues 30-36.
Literature References
PubMed ID Title Journal Year
2159879 Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms

Krämer, S, Tschesche, H, Reinke, H, Knäuper, V

Eur J Biochem 1990
2546891 Activation of neutrophil collagenase by cathepsin G

Berg, RA, Amoruso, MA, Capodici, C, Muthukumaran, G

Inflammation 1989
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of proMMP8 initial activators [extracellular region]

Physical Entity
proMMP8 initial activators [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Activation of proMMP8 (Bos taurus)
Activation of proMMP8 (Caenorhabditis elegans)
Activation of proMMP8 (Canis familiaris)
Activation of proMMP8 (Gallus gallus)
Activation of proMMP8 (Mus musculus)
Activation of proMMP8 (Rattus norvegicus)
Activation of proMMP8 (Sus scrofa)
Activation of proMMP8 (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-09)
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