GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)

Stable Identifier
R-HSA-159826
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
pro-prothrombin, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-prothrombin + 10 H2O + 10 vitamin K epoxide
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GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates ten glutamate residues on F2(25-622) (pro-prothrombin). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Furie et al. 1999; Stenina et al. 2001; Morris et al. 1995).

Literature References
PubMed ID Title Journal Year
10917896 The vitamin K-dependent carboxylase

Berkner, KL

J Nutr 2000
10068650 Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid

Furie, B, Bouchard, BA, Furie, BC

Blood 1999
8530480 Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate.

Morris, DP, Stevens, RD, Wright, DJ, Stafford, DW

J Biol Chem 1995
11513608 Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo

Stenina, O, Pudota, BN, McNally, BA, Hommema, EL, Berkner, KL

Biochemistry 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Created
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