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factor XIIa [extracellular region]
Stable Identifier
R-HSA-158306
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Synonyms
FXIIa
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Defects of contact activation system and kallikrein-kinin system (Homo sapiens)
Aggregated β-amyloid induces FXII autocatalysis (Homo sapiens)
factor XII:β-amyloid:Zn2+-> factor XIIa + β-amyloid:Zn2+ (autocatalysis) (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
Defective SERPING1 causes hereditary angioedema (Homo sapiens)
SERPING1 variant does not bind factor XIIa (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Coagulation pathway (Homo sapiens)
Regulation of clotting cascade (Homo sapiens)
FXIIa, PKa-dependent activation of coagulation pathway (Homo sapiens)
factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
FXIIa activates plasma kallikrein-kinin system (Homo sapiens)
Regulation of FXIIa and plasma kallikrein activity (Homo sapiens)
FXIIa is cleaved to β-FXIIa (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
factor XIIa binds HRG (Homo sapiens)
HRG:factor XIIa [extracellular region] (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
factor XIIa binds SERPING1 (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
factor XIIa:C1Inh [extracellular region] (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
factor XII -> factor XIIa (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) (Homo sapiens)
factor XIIa [extracellular region] (Homo sapiens)
Participants
components
factor XIIa heavy chain [extracellular region]
(Homo sapiens)
factor XIIa light chain [extracellular region]
(Homo sapiens)
Participates
as an input of
SERPING1 variant does not bind factor XIIa (Homo sapiens)
factor XIIa binds HRG (Homo sapiens)
FXIIa is cleaved to β-FXIIa (Homo sapiens)
factor XIIa binds SERPING1 (Homo sapiens)
as an output of
factor XII:β-amyloid:Zn2+-> factor XIIa + β-amyloid:Zn2+ (autocatalysis) (Homo sapiens)
kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) (Homo sapiens)
factor XII -> factor XIIa (Homo sapiens)
factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) (Homo sapiens)
prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) (Homo sapiens)
as a component of
HRG:factor XIIa [extracellular region] (Homo sapiens)
factor XIIa:C1Inh [extracellular region] (Homo sapiens)
Inferred To
factor XIIa [extracellular region]
(Bos taurus)
factor XIIa [extracellular region]
(Gallus gallus)
factor XIIa [extracellular region]
(Mus musculus)
factor XIIa [extracellular region]
(Rattus norvegicus)
factor XIIa [extracellular region]
(Sus scrofa)
factor XIIa [extracellular region]
(Xenopus tropicalis)
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