Reactome | factor XIIa binds SERPING1

factor XIIa binds SERPING1

Stable Identifier

R-HSA-158357

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

factor XIIa + C1Inh -> factor XIIa:C1Inh

ReviewStatus

5/5

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Activated factor XII (factor XIIa) binds to the plasma protease C1 inhibitor (C1INH, encoded by the SERPING1 gene) (Bock SC., et al. 1986) to form a stable, inactive complex (Schneider AD et al., 1973). While several protease inhibitors can form stable complexes with XIIa in vitro, only C1INH does so to a significant extent under normal conditions in vivo (Pixley RA et al. 1985). C1INH accounts for 92% inhibition of FXIIa in plasma (Pixley RA et al., 1985).

Literature References

PubMed ID	Title	Journal	Year
3756141	Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization Bock, SC, Skriver, K, Nielsen, E, Thogersen, HC, Wiman, B, Donaldson, VH, Eddy, RL, Marrinan, J, Radziejewska, E, Huber, R, Magnusson, S	Biochemistry	1986
2578463	The regulation of human factor XIIa by plasma proteinase inhibitors Pixley, RA, Schapira, M, Colman, RW	J Biol Chem	1985
4703226	Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation Schreiber, AD, Kaplan, AP, Austen, KF	J Clin Invest	1973