factor XIIa binds SERPING1

Stable Identifier
Reaction [binding]
Homo sapiens
factor XIIa + C1Inh -> factor XIIa:C1Inh
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Activated factor XII (factor XIIa) binds to C1Inh (C1 inhibitor - Bock et al. 1986) to form a stable, inactive complex (Schneider et al. 1973). While several protease inhibitors can form stable complexes with XIIa in vitro, only C1Inh does so to a significant extent under normal conditions in vivo (Pixley et al. 1985).

Literature References
PubMed ID Title Journal Year
3756141 Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization

Nielsen, E, Marrinan, J, Donaldson, VH, Thogersen, HC, Skriver, K, Eddy, RL, Magnusson, S, Bock, SC, Wiman, B, Huber, R, Radziejewska, E

Biochemistry 1986
2578463 The regulation of human factor XIIa by plasma proteinase inhibitors

Schapira, M, Pixley, RA, Colman, RW

J Biol Chem 1985
4703226 Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation

Kaplan, AP, Austen, KF, Schreiber, AD

J Clin Invest 1973
Event Information
Orthologous Events
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