Reactome | factor XIIa [extracellular region]

factor XIIa [extracellular region]

Stable Identifier

R-RNO-158306

Type

Complex

Species

Rattus norvegicus

Compartment

extracellular region

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

F12 [extracellular region] (Rattus norvegicus)
F12 [extracellular region] (Rattus norvegicus)

Participates

as a component of

HRG:factor XIIa [extracellular region] (Rattus norvegicus)
factor XIIa:C1Inh [extracellular region] (Rattus norvegicus)

as an input of

factor XIIa binds HRG (Rattus norvegicus)
FXIIa is cleaved to β-FXIIa (Rattus norvegicus)
factor XIIa binds SERPING1 (Rattus norvegicus)

as an output of

kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) (Rattus norvegicus)
factor XII -> factor XIIa (Rattus norvegicus)
factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) (Rattus norvegicus)
prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) (Rattus norvegicus)

Inferred From

factor XIIa [extracellular region] (Homo sapiens)

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