Mtb iron assimilation by chelation

Stable Identifier
R-HSA-1222449
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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Uptake of iron in Mtb, especially when the bacterium is in the host, strongly depends on siderophores. Humans, through secretion of lactoferrin, maintain an iron concentration of 10^(-18) M within macrophages, and the bacterium has evolved the siderophores mycobactin T and exomycobactin T (formerly exochelin) to cope with this shortage. While nonpolar mycobactin T stays in the cell wall and only moves around in liquid droplets, polar exochelin is abundantly secreted. As it can bind iron with higher affinity than lactoferrin, it frequently scavenges iron ions from this molecule (Miethke & Marahiel 2007).

Literature References
PubMed ID Title Journal Year
17804665 Siderophore-based iron acquisition and pathogen control

Miethke, M, Marahiel, MA

Microbiol Mol Biol Rev 2007
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created