Reactome | PI and PC transport between ER and Golgi membranes

PI and PC transport between ER and Golgi membranes

Stable Identifier

R-HSA-1483196

DOI

10.3180/R-HSA-1483196.4

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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PI and PC transport between ER and Golgi membranes

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The phosphatidylinositol transfer protein beta isoform (PITPNB) bound to phosphatidylinositol (PI) complex transports from the endoplasmic reticulum (ER) membrane to the Golgi membrane, where phosphatidylcholine (PC) is exchanged for PI. PITPNB now in complex with PC transports back to the ER membrane where PI is now exchanged for PC, and the cycle repeats. This process has been characterized in detail in bovine and rodent model systems (e.g., Wirtz et al. 2006; Ghosh and Bankaitis 2011), which provide a framework for organizing the more limited data available for the very well conserved human proteins and processes( Carvou et al. 2010, Shadan et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
21915936	Phosphatidylinositol transfer proteins: negotiating the regulatory interface between lipid metabolism and lipid signaling in diverse cellular processes Ghosh, R, Bankaitis, VA	Biofactors	2011
18636990	Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells Shadan, S, Holic, R, Carvou, N, Ee, P, Li, M, Murray-Rust, J, Cockcroft, S	Traffic	2008
16854452	Phosphatidylinositol transfer proteins: from closed for transport to open for exchange Wirtz, KWA, Schouten, A, Gros, P	Adv Enzyme Regul	2006
20332109	Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum Carvou, N, Holic, R, Li, M, Futter, C, Skippen, A, Cockcroft, S	J Cell Sci	2010