PI and PC transport between ER and Golgi membranes

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser
The phosphatidylinositol transfer protein beta isoform (PITPNB) bound to phosphatidylinositol (PI) complex transports from the endoplasmic reticulum (ER) membrane to the Golgi membrane, where phosphatidylcholine (PC) is exchanged for PI. PITPNB now in complex with PC transports back to the ER membrane where PI is now exchanged for PC, and the cycle repeats. This process has been characterized in detail in bovine and rodent model systems (e.g., Wirtz et al. 2006; Ghosh and Bankaitis 2011), which provide a framework for organizing the more limited data available for the very well conserved human proteins and processes( Carvou et al. 2010, Shadan et al. 2008).
Literature References
PubMed ID Title Journal Year
21915936 Phosphatidylinositol transfer proteins: negotiating the regulatory interface between lipid metabolism and lipid signaling in diverse cellular processes

Bankaitis, VA, Ghosh, R

Biofactors 2011
18636990 Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells

Ee, P, Murray-Rust, J, Li, M, Carvou, N, Shadan, S, Holic, R, Cockcroft, S

Traffic 2008
16854452 Phosphatidylinositol transfer proteins: from closed for transport to open for exchange

Schouten, A, Gros, P, Wirtz, KWA

Adv Enzyme Regul 2006
20332109 Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum

Li, M, Skippen, A, Carvou, N, Holic, R, Cockcroft, S, Futter, C

J Cell Sci 2010
Event Information
Go Biological Process
Orthologous Events
Cite Us!