Reactome | PI is exchanged with PC by PITPNB

PI is exchanged with PC by PITPNB

Stable Identifier

R-HSA-1483087

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Phospholipid metabolism (Homo sapiens)
    - Glycerophospholipid biosynthesis (Homo sapiens)
      - PI and PC transport between ER and Golgi membranes (Homo sapiens)
        
        PI is exchanged with PC by PITPNB (Homo sapiens)
    - PI Metabolism (Homo sapiens)
      - PI and PC transport between ER and Golgi membranes (Homo sapiens)
        
        PI is exchanged with PC by PITPNB (Homo sapiens)

General

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At the Golgi membrane, phosphatidylinositol (PI) is exchanged for phosphatidylcholine (PC) within the phosphatidylinositol transfer protein beta isoform (PITPNB) complex (Tilley et al. 2004, Yoder et al. 2001, Carvou et al. 2010, Schouten et al. 2002, Vordtriede et al. 2005, Shadan et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
11980708	Structure of apo-phosphatidylinositol transfer protein alpha provides insight into membrane association Schouten, A, Agianian, B, Gros, P, Wirtz, KWA, Kroon, J, Westerman, J	EMBO J	2002
18636990	Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells Ee, P, Murray-Rust, J, Li, M, Carvou, N, Shadan, S, Holic, R, Cockcroft, S	Traffic	2008
11104777	Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine Yarbrough, LR, Helmkamp GM, Jr, Oliver, RL, Tremblay, JM, Yoder, MD, Thomas, LM	J Biol Chem	2001
20332109	Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum Li, M, Skippen, A, Carvou, N, Holic, R, Cockcroft, S, Futter, C	J Cell Sci	2010
14962392	Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol Tilley, SJ, Murray-Rust, J, Skippen, A, Stewart, A, McDonald, NQ, Swigart, PM, Morgan, CP, Cockcroft, S	Structure	2004
16274224	Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms Helmkamp GM, Jr, Tremblay, JM, Doan, CN, Yoder, MD, Vordtriede, PB	Biochemistry	2005