Reactome | Inactivation of APC/C via direct inhibition of the APC/C complex

Inactivation of APC/C via direct inhibition of the APC/C complex

Stable Identifier

R-HSA-141430

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)

General

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Inactivation of APC/C via direct inhibition of the APC/C complex

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In the direct inhibition model, the cytosolic Mitotic Checkpoint Complex, consisting of hBUBR1, hBUB3, Cdc20 and Mad2, directly inhibits APC/C by binding to it.

Literature References

PubMed ID	Title	Journal	Year
14593737	The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit Yen, TJ, Chan, GK	Prog Cell Cycle Res	2003
11535616	Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 Yen, TJ, Sudakin, V, Chan, GK	J Cell Biol	2001
9637688	The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation Yu, H, Fang, G, Kirschner, MW	Genes Dev	1998