Binding of the MCC complex to the APC/C complex

Stable Identifier
R-HSA-141423
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In the direct inhibition model, association of the MCC with APCC results in the inactivation of APC/C. However, the affinity between MCC and APC/C is not high, so that the inhibition is readily reversible. The role of unattached kinetochores is to sensitize the APC/C to prolonged inhibition by the MCC.

Literature References
PubMed ID Title Journal Year
11535616 Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

Sudakin, V, Chan, GK, Yen, TJ

J Cell Biol 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created