Binding of the MCC complex to the APC/C complex

Stable Identifier
R-HSA-141423
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Binding of the MCC complex to the APC/C complex
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In the direct inhibition model, association of the MCC with APCC results in the inactivation of APC/C. However, the affinity between MCC and APC/C is not high, so that the inhibition is readily reversible. The role of unattached kinetochores is to sensitize the APC/C to prolonged inhibition by the MCC.

Literature References
PubMed ID Title Journal Year
11535616 Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

Yen, TJ, Sudakin, V, Chan, GK

J Cell Biol 2001
Participants
Input
Output
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as an event of
Orthologous Events
Binding of the MCC complex to the APC/C complex (Bos taurus)
Binding of the MCC complex to the APC/C complex (Canis familiaris)
Binding of the MCC complex to the APC/C complex (Danio rerio)
Binding of the MCC complex to the APC/C complex (Dictyostelium discoideum)
Binding of the MCC complex to the APC/C complex (Drosophila melanogaster)
Binding of the MCC complex to the APC/C complex (Gallus gallus)
Binding of the MCC complex to the APC/C complex (Mus musculus)
Binding of the MCC complex to the APC/C complex (Rattus norvegicus)
Binding of the MCC complex to the APC/C complex (Sus scrofa)
Authored
Yen, TJ  (2004-05-05)
Reviewed
Peters, JM  (2006-03-28)
Created
Yen, TJ  (2004-05-05)
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