Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

Stable Identifier
R-HSA-141405
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
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The target of the mitotic checkpoint is the Anaphase Promoting Complex/Cyclosome (APC/C) an E3 ubiquitin ligase that targets proteins whose destruction is essential for mitotic exit. Currently, there are two proposed mechanism by which inhibition of the APC/C is achieved. These mechanisms differ depending on the mechanism of signal transduction. The APC/C may be inhibited directly by association with the Mitotic Checkpoint Complex (MCC) or through the sequestration of its activator, Cdc20.

Literature References
PubMed ID Title Journal Year
14593737 The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit

Yen, TJ, Chan, GK

Prog Cell Cycle Res 2003
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Orthologous Events
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Bos taurus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Caenorhabditis elegans)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Canis familiaris)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Danio rerio)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Dictyostelium discoideum)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Drosophila melanogaster)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Gallus gallus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Mus musculus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Rattus norvegicus)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Saccharomyces cerevisiae)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Schizosaccharomyces pombe)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Sus scrofa)
Cross References
BioModels Database
Authored
Yen, TJ  (2004-05-05)
Reviewed
Peters, JM  (2006-03-28)
Created
Yen, TJ  (2004-05-05)
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