TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]

Stable Identifier
R-HSA-140946
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
GO Cellular Component
death-inducing signaling complex (0031264)
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
12721308 Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis

Cohen, GM, Hughes, M, Harper, N, MacFarlane, M

J. Biol. Chem. 2003
10892748 A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

Liou, HC, Wu, H, Hsia, C, Rich, RL, Park, YC, Myszka, DG, Segal, D, Ye, H

Cell 2000
17633020 Structural revelations of TRAF2 function in TNF receptor signaling pathway

Yin, Q, Wu, H, Lu, M, Chung, JY

Adv. Exp. Med. Biol. 2007
12887920 Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O, Tschopp, J

Cell 2003
Participants
components
Participates
as an output of
as a component of
as an input of
as a member of
Inferred To
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Danio rerio)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Xenopus tropicalis)
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