TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]

Stable Identifier
R-HSA-140946
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
GO Cellular Component
death-inducing signaling complex (0031264)
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
12721308 Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis

Harper, N, Hughes, M, MacFarlane, M, Cohen, GM

J. Biol. Chem. 2003
10892748 A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

Park, YC, Ye, H, Hsia, C, Segal, D, Rich, RL, Liou, HC, Myszka, DG, Wu, H

Cell 2000
17633020 Structural revelations of TRAF2 function in TNF receptor signaling pathway

Chung, JY, Lu, M, Yin, Q, Wu, H

Adv. Exp. Med. Biol. 2007
12887920 Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O, Tschopp, J

Cell 2003
Participants
components
Participates
as a component of
as an input of
as a member of
as an output of
Inferred To
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Bos taurus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Danio rerio)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Gallus gallus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Mus musculus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Rattus norvegicus)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Sus scrofa)
TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Xenopus tropicalis)
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