Reactome | TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]

TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]

Stable Identifier

R-CFA-140946

Type

Complex

Species

Canis familiaris

Compartment

plasma membrane

Locations in the PathwayBrowser

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

RIPK1 [cytosol] (Canis familiaris)
TNF-α trimer:TNFR1 trimer [plasma membrane] (Canis familiaris)
x 3 TRADD [cytosol] (Canis familiaris)
x 3 TRAF2 [cytosol] (Canis familiaris)

Participates

as an output of

CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)

as an input of

MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Canis familiaris)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Canis familiaris)

as a component of

TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Canis familiaris)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Canis familiaris)

as a member of

RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Canis familiaris)

Inferred From

TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] (Homo sapiens)

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