Reactome | BBC3 [cytosol]

BBC3 [cytosol]

Stable Identifier

R-HSA-140220

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PUMA protein

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BXH1 BBC3

Gene Names

BBC3, PUMA

Chain

chain:1-193

Reference Genes

BioGPS Gene:27113 BBC3B

COSMIC (genes):BBC3 BBC3

CTD Gene:27113 BBC3B

dbSNP Gene:27113 BBC3B

ENSEMBL:ENSG00000105327 BBC3

HGNC:17868 BBC3B

KEGG:hsa:27113 BBC3B

Monarch:27113 BBC3B

NCBI Gene:27113 BBC3B

OMIM:605854 BBC3B

UCSC:Q9BXH1 BBC3

Reference Transcript

Participates

as an output of

as an input of

Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)

Other forms of this molecule

BBC3 [mitochondrial outer membrane]

Cross References

RefSeq

NP_055232.1, NP_001120712.1, NP_001120714.1, XP_054176516.1, XP_054176518.1, NP_001120713.1, XP_006723204.1, XP_047294562.1

OpenTargets

ENSG00000105327

ENSEMBL

ENSP00000341155, ENST00000439096, ENSG00000105327, ENSP00000395862, ENST00000341983

GeneCards

BBC3

PRO

Q9BXH1

Pharos - Targets

Q9BXH1

PDB

6QG8, 2M04, 5UUL, 7DVD, 6TQP, 7P0S, 7QTX, 4HNJ, 7P9W, 4BPI, 4BPK, 4BPJ, 6QFM

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07817-1 BCL2L1			0.855	9
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.815	6
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.813	6
UniProt:Q92843 B2CL2			0.779	4
UniProt:P97287 MCL1			0.71	5
UniProt:Q07817 BCL2L1	2	BCL2L1 [mitochondrial outer membrane] (R-HSA-114236) BCL2L1 [cytosol] (R-HSA-50771)	0.59	2

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