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BBC3 [cytosol]
Stable Identifier
R-HSA-140220
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PUMA protein
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell death genes (Homo sapiens)
BBC3 gene expression is stimulated by FOXO3,(FOXO1) (Homo sapiens)
BBC3 [cytosol] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
BBC3 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of PUMA and translocation to mitochondria (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
BBC3 [cytosol] (Homo sapiens)
Transactivation of BBC3 (PUMA) by E2F1 (Homo sapiens)
BBC3 [cytosol] (Homo sapiens)
Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)
BBC3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BXH1 BBC3
Gene Names
BBC3, PUMA
Chain
chain:1-193
Reference Genes
COSMIC (genes):BBC3 BBC3
dbSNP Gene:27113 BBC3
ENSEMBL:ENSG00000105327 BBC3
Participates
as an output of
BBC3 gene expression is stimulated by FOXO3,(FOXO1) (Homo sapiens)
Transactivation of BBC3 (PUMA) by E2F1 (Homo sapiens)
TP53 stimulates BBC3 (PUMA) expression (Homo sapiens)
as an input of
Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)
Other forms of this molecule
BBC3 [mitochondrial outer membrane]
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07817-1 BCL2L1
0.855
9
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.815
6
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.759
5
UniProt:Q92843 B2CL2
0.713
3
UniProt:P97287 MCL1
0.71
5
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