Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
BBC3 [mitochondrial outer membrane]
Stable Identifier
R-HSA-140222
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
PUMA protein
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of PUMA and translocation to mitochondria (Homo sapiens)
Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)
BBC3 [mitochondrial outer membrane] (Homo sapiens)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members (Homo sapiens)
BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL (Homo sapiens)
Bcl-XL interacting BH3-only proteins [mitochondrial outer membrane] (Homo sapiens)
BBC3 [mitochondrial outer membrane] (Homo sapiens)
Bcl-XL:BH3-only protein complex [mitochondrial outer membrane] (Homo sapiens)
Bcl-XL interacting BH3-only proteins [mitochondrial outer membrane] (Homo sapiens)
BBC3 [mitochondrial outer membrane] (Homo sapiens)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 (Homo sapiens)
Bcl-2 interacting BH-3 only proteins [mitochondrial outer membrane] (Homo sapiens)
BBC3 [mitochondrial outer membrane] (Homo sapiens)
Bcl2:BH3-only protein complex [mitochondrial outer membrane] (Homo sapiens)
Bcl-2 interacting BH-3 only proteins [mitochondrial outer membrane] (Homo sapiens)
BBC3 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BXH1 BBC3
Gene Names
BBC3, PUMA
Chain
chain:1-193
Reference Genes
BioGPS Gene:27113 BBC3B
COSMIC (genes):BBC3 BBC3
CTD Gene:27113 BBC3B
dbSNP Gene:27113 BBC3B
ENSEMBL:ENSG00000105327 BBC3
HGNC:17868 BBC3B
KEGG:hsa:27113 BBC3B
Monarch:27113 BBC3B
NCBI Gene:27113 BBC3B
OMIM:605854 BBC3B
UCSC:Q9BXH1 BBC3
Reference Transcript
RefSeq:XM_006723141.3 BBC3
RefSeq:NM_001127240.2 BBC3B
RefSeq:NM_001127241.2 BBC3
RefSeq:NM_014417.4 BBC3
RefSeq:NM_001127242.2 BBC3B
Participates
as a member of
Bcl-XL interacting BH3-only proteins [mitochondrial outer membrane] (Homo sapiens)
Bcl-2 interacting BH-3 only proteins [mitochondrial outer membrane] (Homo sapiens)
as an output of
Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)
Other forms of this molecule
BBC3 [cytosol]
Cross References
ENSEMBL
ENSG00000105327
,
ENST00000341983
,
ENST00000439096
,
ENSP00000395862
,
ENSP00000341155
OpenTargets
ENSG00000105327
GeneCards
BBC3
PRO
Q9BXH1
Pharos - Targets
Q9BXH1
PDB
4HNJ
,
6QG8
,
7P9W
,
5UUL
,
6TQP
,
7QTX
,
7P0S
,
2M04
,
6QFM
,
7DVD
,
4BPK
,
4BPI
,
4BPJ
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07817-1 BCL2L1
0.855
9
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.815
6
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.759
5
UniProt:Q92843 B2CL2
0.713
3
UniProt:P97287 MCL1
0.71
5
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text