BBC3 gene expression is stimulated by FOXO3,(FOXO1)

Stable Identifier
Reaction [omitted]
Homo sapiens
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Transcription of the pro-apoptotic BBC3 (PUMA) gene is directly stimulated by FOXO3 (Dudgeon et al. 2010, Fitzwalter et al. 2018). FOXO1 upregulates BBC3 transcription (Hughes et al. 2011, Liu et al. 2015, Wu et al. 2016, Liu et al. 2017), but direct binding to the BBC3 gene locus has not been demonstrated.
FOXO-mediated upregulation of BBC3 gene transcription is positively regulated by DDIT3 (CHOP) through an unknown mechanism. DDIT3 is able to bind FOXO3, but the physiological role and context of this protein complex is not known (Ghosh et al. 2012).

Literature References
PubMed ID Title Journal Year
20978166 PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01

Yu, J, Wang, P, Dudgeon, C, Sun, Q, Sun, X, Zhang, L, Peng, R

Mol. Cancer Ther. 2010
29533771 Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover

Towers, CG, Morgan, MJ, Sullivan, KD, Ryan, KM, Fitzwalter, BE, O'Prey, J, Ludwig, M, Thorburn, A, Hoh, M, Espinosa, JM, Andrysik, Z

Dev. Cell 2018
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