Translocation of BBC3 (PUMA) protein to mitochondria

Stable Identifier
R-HSA-139914
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
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Translocation of BBC3 (PUMA) protein to mitochondria
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It is thought that due to its p53 dependence for expression, PUMA could function as a mediator of p53-induced apoptosis. Newly synthesized PUMA protein translocates to mitochondria and binds to BCL-2 and Bcl-X(L) through a BH3 domain.

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Output
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hasEvent
Event Information
Go Biological Process
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (0001844)
Authored
Gopinathrao, G  (2004-08-18)
Reviewed
Vaux, DL  (2019-11-13)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)