Activation of PUMA and translocation to mitochondria

Stable Identifier
R-HSA-139915
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of PUMA and translocation to mitochondria
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Puma is transactivated in a p53-dependent manner and by E2F1. Activated Puma is translocated to mitochondria.

Literature References
PubMed ID Title Journal Year
14684737 Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

Hershko, T, Ginsberg, D

J Biol Chem 2004
11463392 PUMA, a novel proapoptotic gene, is induced by p53

Nakano, K, Vousden, KH

Mol Cell 2001
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Event Information
Go Biological Process
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (1900740)
Created
Hardwick, JM  (2004-08-09)
Tsujimoto, Y  (2004-08-09)
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