Activation of PUMA and translocation to mitochondria

Stable Identifier
R-HSA-139915
Type
Pathway
Species
Homo sapiens
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Puma is transactivated in a p53-dependent manner and by E2F1. Activated Puma is translocated to mitochondria.

Literature References
PubMed ID Title Journal Year
11463392 PUMA, a novel proapoptotic gene, is induced by p53

Nakano, K, Vousden, KH

Mol Cell 2001
14684737 Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

Hershko, T, Ginsberg, D

J Biol Chem 2004
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