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p-5Y-EGFRvIII mutant dimer [plasma membrane]
Stable Identifier
R-HSA-1248654
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Activated phospho-EGFRvIIImut:HSP90:CDC37
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by EGFRvIII in Cancer (Homo sapiens)
Constitutive Signaling by EGFRvIII (Homo sapiens)
Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
EGFRvIII does not bind CBL (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant (Homo sapiens)
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Phosphorylation of SHC1 by p-5Y-EGFRvIII (Homo sapiens)
p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII) (Homo sapiens)
p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII) (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)
p-5Y-EGFRvIII mutant dimer [plasma membrane] (Homo sapiens)
Participants
components
x 2
Phospho-EGFRvIIImut:HSP90:CDC37 [plasma membrane]
(Homo sapiens)
Participates
as an output of
Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant (Homo sapiens)
Trans-autophosphorylation of EGFRvIII mutant dimers (Homo sapiens)
as an input of
Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII (Homo sapiens)
PLC-gamma 1 binds to p-EGFRvIII mutant (Homo sapiens)
EGFRvIII does not bind CBL (Homo sapiens)
Binding of GRB2:GAB1 complex to p-EGFRvIII mutant (Homo sapiens)
Binding of SHC1 to p-5Y-EGFRvIII (Homo sapiens)
as a component of
p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y771,Y783,Y1254-PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:PLCG1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:GRB2:GAB1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:SHC1 [plasma membrane] (Homo sapiens)
p-5Y-EGFRvIII:p-Y349,Y350-SHC1 [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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