Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII

Stable Identifier
R-HSA-5637770
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Binding of GRB2:SOS1 to p-EGFRvIII
Locations in the PathwayBrowser
Summation

Direct binding of GRB2:SOS1 complex to phosphorylated homodimers of EGFRvIII cancer mutant has not been tested. GRB2 binds to phosphorylated tyrosine residues Y1068 and Y1086 (corresponding to Y1092 and Y1110, respectively, when counting from the first amino acid of the EGFR precursor, prior to cleavage of the 24-amino acid signal peptide at the N-terminus). Phosphorylation of Y1068 (i.e. Y1092) has been directly demonstrated in EGFRvIII mutant (Huang et al. 2007).

Literature References
PubMed ID Title Journal Year
17646646 Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

Huang, PH, Mukasa, A, Bonavia, R, Flynn, RA, Brewer, ZE, Cavenee, WK, Furnari, FB, White, FM

Proc Natl Acad Sci U S A 2007
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created