Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII

Stable Identifier
R-HSA-5637770
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Binding of GRB2:SOS1 to p-EGFRvIII
Locations in the PathwayBrowser
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Direct binding of GRB2:SOS1 complex to phosphorylated homodimers of EGFRvIII cancer mutant has not been tested. GRB2 binds to phosphorylated tyrosine residues Y1068 and Y1086 (corresponding to Y1092 and Y1110, respectively, when counting from the first amino acid of the EGFR precursor, prior to cleavage of the 24-amino acid signal peptide at the N-terminus). Phosphorylation of Y1068 (i.e. Y1092) has been directly demonstrated in EGFRvIII mutant (Huang et al. 2007).

Literature References
PubMed ID Title Journal Year
17646646 Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

Huang, PH, Mukasa, A, Bonavia, R, Flynn, RA, Brewer, ZE, Cavenee, WK, Furnari, FB, White, FM

Proc Natl Acad Sci U S A 2007
Participants
Participates
Normal reaction
Functional status

Gain of function of p-5Y-EGFRvIII mutant dimer [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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