Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant

Stable Identifier
R-HSA-5637800
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Once phosphorylated, PLC-gamma 1 is expected to dissociate from phosphorylated EGFRvIII cancer mutant and induce downstream signaling in the same way it does when activated by the wild-type EGFR. However, except for the phosphorylation of PLCG1 binding site in EGFRvIII (Grandal et al. 2007), other events involved in activation of PLCG1 signaling have not been studied in cells expressing EGFRvIII.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Carpenter, G, Ji, Q

Exp Cell Res 1999
17372273 EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes

Grandal, MV, Zandi, R, Pedersen, MW, Willumsen, BM, van Deurs, B, Poulsen, HS

Carcinogenesis 2007
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
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