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VEGFA [extracellular region]
Stable Identifier
R-HSA-2975974
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Vascular endothelial growth factor A, VEGFA_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Regulation of gene expression by Hypoxia-inducible Factor (Homo sapiens)
Expression of VEGFA (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors (Homo sapiens)
VEGFA gene expression is inhibited by the TFAP2A homodimer (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
VEGFs [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
AAMP gene expression is positively regulated by VEGF (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGF ligand-receptor interactions (Homo sapiens)
Homodimerization of VEGF proteins (Homo sapiens)
VEGF [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGF dimer [extracellular region] (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGF binds to VEGFR leading to receptor dimerization (Homo sapiens)
VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization (Homo sapiens)
VEGFA,C,D dimers [extracellular region] (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGFR2:VEGFA,C,D [plasma membrane] (Homo sapiens)
VEGFA,C,D dimers [extracellular region] (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization (Homo sapiens)
VEGFA,VEGFB,PGF dimers [extracellular region] (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
VEGFR1 dimer:VEGFA, VEGFB, PGF dimers [plasma membrane] (Homo sapiens)
VEGFA,VEGFB,PGF dimers [extracellular region] (Homo sapiens)
VEGFA dimer [extracellular region] (Homo sapiens)
VEGFA [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15692 VEGFA
Gene Names
VEGFA, VEGF
Chain
chain:1-395, chain:1-, chain:-395
Reference Genes
BioGPS Gene:7422 VEGFA
COSMIC (genes):VEGFA VEGFA
CTD Gene:7422 VEGFA
dbSNP Gene:7422 VEGFA
ENSEMBL:ENSG00000112715 VEGFA
ENSEMBL:ENSG00000112715.26 VEGFA
HGNC:12680 VEGFA
KEGG Gene (Homo sapiens):7422 VEGFA
Monarch:7422 VEGFA
NCBI Gene:7422 VEGFA
OMIM:192240 VEGFA
UCSC:P15692 VEGFA
Reference Transcript
RefSeq:NM_001171630.1 VEGFA
RefSeq:NM_001287044.1 VEGFA
RefSeq:NM_001171622.1 VEGFA
RefSeq:NM_001025368.2 VEGFA
RefSeq:NM_001171627.1 VEGFA
RefSeq:NM_001204385.1 VEGFA
RefSeq:NM_003376.5 VEGFA
RefSeq:NM_001171624.1 VEGFA
RefSeq:NM_001033756.2 VEGFA
RefSeq:NM_001025367.2 VEGFA
RefSeq:NM_001171629.1 VEGFA
RefSeq:NM_001025370.2 VEGFA
RefSeq:NM_001171626.1 VEGFA
RefSeq:NM_001317010.1 VEGFA
RefSeq:NM_001204384.1 VEGFA
RefSeq:NM_001025366.2 VEGFA
RefSeq:NM_001171623.1 VEGFA
RefSeq:NM_001171628.1 VEGFA
RefSeq:NM_001025369.2 VEGFA
RefSeq:NM_001171625.1 VEGFA
Other Identifiers
11725370_s_at
11725371_s_at
11725372_x_at
11738414_a_at
11741964_s_at
11741965_x_at
11750313_x_at
11755745_x_at
17009093
1953_at
210512_PM_s_at
210512_s_at
210513_PM_s_at
210513_s_at
211527_PM_x_at
211527_x_at
212171_PM_x_at
212171_x_at
2908180
2908181
2908182
2908186
2908189
2908192
2908194
2908196
2908197
2908200
2908202
2908203
2908204
2908205
2908207
36100_at
36101_s_at
73146_at
7422
8119898
A_14_P121725
A_14_P138589
A_23_P81805
A_24_P12401
A_24_P179400
GE54171
GE767555
GO:0000122
GO:0001525
GO:0001541
GO:0001569
GO:0001570
GO:0001666
GO:0001701
GO:0001822
GO:0001934
GO:0001938
GO:0001968
GO:0002040
GO:0002042
GO:0002052
GO:0002092
GO:0002376
GO:0002575
GO:0002687
GO:0003007
GO:0003013
GO:0003151
GO:0003169
GO:0005125
GO:0005161
GO:0005172
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005912
GO:0006351
GO:0006355
GO:0006357
GO:0007155
GO:0007165
GO:0007399
GO:0007498
GO:0007595
GO:0008083
GO:0008201
GO:0008284
GO:0008360
GO:0009986
GO:0010595
GO:0010628
GO:0010629
GO:0010749
GO:0012501
GO:0014068
GO:0016020
GO:0016192
GO:0022414
GO:0023052
GO:0030141
GO:0030154
GO:0030224
GO:0030225
GO:0030312
GO:0030324
GO:0030335
GO:0030855
GO:0031012
GO:0031077
GO:0031093
GO:0031334
GO:0031410
GO:0031954
GO:0032147
GO:0032793
GO:0033138
GO:0034330
GO:0035148
GO:0035767
GO:0035924
GO:0036211
GO:0036303
GO:0036324
GO:0038033
GO:0038084
GO:0038089
GO:0038091
GO:0038190
GO:0038191
GO:0042056
GO:0042060
GO:0042327
GO:0042462
GO:0042802
GO:0042803
GO:0043066
GO:0043117
GO:0043129
GO:0043154
GO:0043183
GO:0043184
GO:0043226
GO:0043406
GO:0043410
GO:0043536
GO:0045766
GO:0045785
GO:0045944
GO:0048010
GO:0048018
GO:0048469
GO:0048593
GO:0048842
GO:0048844
GO:0048856
GO:0048870
GO:0050679
GO:0050731
GO:0050840
GO:0050918
GO:0050927
GO:0050930
GO:0051781
GO:0051894
GO:0051897
GO:0055013
GO:0060319
GO:0060749
GO:0060754
GO:0060948
GO:0060982
GO:0061042
GO:0061419
GO:0065003
GO:0070374
GO:0071456
GO:0071542
GO:0071679
GO:0090037
GO:0090050
GO:0090190
GO:0090259
GO:0097475
GO:0097533
GO:0098772
GO:0120162
GO:1900086
GO:1900745
GO:1900748
GO:1901165
GO:1901727
GO:1902336
GO:1902966
GO:1903141
GO:1903392
GO:1903572
GO:1903589
GO:1903672
GO:1905278
GO:1905604
GO:1990150
GO:2000048
GO:2000573
HMNXSV003013113
Hs.73793.2.S2_3p_a_at
ILMN_1693060
ILMN_1803882
ILMN_2375879
M27281_at
PH_hs_0004213
TC06000608.hg
TC06002799.hg
g340300_3p_a_at
g3719220_3p_a_at
g5901560_3p_a_at
g5901560_3p_s_at
Participates
as a member of
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
VEGFs [extracellular region] (Homo sapiens)
VEGF [extracellular region] (Homo sapiens)
as an output of
VEGFA gene expression is inhibited by the TFAP2A homodimer (Homo sapiens)
Expression of VEGFA (Homo sapiens)
as a component of
VEGFA dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
VEGFA [platelet alpha granule lumen]
Inferred To
Vegfa [extracellular region]
(Mus musculus)
Vegfa [extracellular region]
(Rattus norvegicus)
vegfa [extracellular region]
(Xenopus tropicalis)
VEGFA [extracellular region]
(Bos taurus)
VEGFA [extracellular region]
(Canis familiaris)
VEGFA [extracellular region]
(Danio rerio)
VEGFA [extracellular region]
(Gallus gallus)
VEGFA [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001020541.2
,
NP_001165095.1
,
NP_001020538.2
,
NP_001165101.1
,
NP_001165098.1
,
NP_001165093.1
,
NP_001028928.1
,
NP_001165096.1
,
NP_001165099.1
,
NP_001020539.2
,
NP_001191314.1
,
NP_001165100.1
,
NP_001303939.1
,
NP_001165094.1
,
NP_003367.4
,
NP_001020540.2
,
NP_001020537.2
,
NP_001273973.1
,
NP_001191313.1
,
NP_001165097.1
OpenTargets
ENSG00000112715
ZINC - Substances
VEGFA_HUMAN
ZINC target
P15692
ZINC - Biogenic
VEGFA_HUMAN
PRO
P15692
PDB
1QTY
,
7LL8
,
4GLN
,
2QR0
,
5HHD
,
1CZ8
,
2FJG
,
6Z13
,
5FV1
,
3S1B
,
7KF1
,
5DN2
,
1TZI
,
1FLT
,
6ZCD
,
1KAT
,
5O4E
,
3V2A
,
4WPB
,
6Z3F
,
3BDY
,
6T9D
,
2FJH
,
6ZBR
,
4GLS
,
1VPF
,
6BFT
,
5FV2
,
2VGH
,
3S1K
,
1VGH
,
1MKG
,
4KZN
,
1BJ1
,
4ZFF
,
6V7K
,
3QTK
,
5HHC
,
1TZH
,
1VPP
,
1KMX
,
7KEZ
,
7KF0
,
2VPF
,
4DEQ
,
3P9W
,
6ZFL
,
5T89
,
1MJV
,
1MKK
,
4QAF
,
6D3O
,
7LL9
ZINC - Metabolites
VEGFA_HUMAN
GeneCards
P15692
HPA
ENSG00000112715-VEGFA
Ensembl
ENSP00000428321
,
ENST00000372055
,
ENST00000372077
,
ENST00000523125
,
ENSP00000421561
,
ENST00000518824
,
ENSP00000361137
,
ENSP00000317598
,
ENST00000518689
,
ENST00000324450
,
ENSP00000430479
,
ENST00000372067
,
ENST00000482630
,
ENSP00000429643
,
ENST00000520948
,
ENST00000372064
,
ENSP00000429008
,
ENSP00000361134
,
ENSP00000389864
,
ENSP00000388663
,
ENSP00000409911
,
ENSP00000500082
,
ENST00000672860
,
ENST00000417285
,
ENST00000523950
,
ENSP00000361125
,
ENSG00000112715
,
ENSP00000361148
,
ENST00000523873
,
ENST00000457104
,
ENST00000413642
,
ENSP00000430002
,
ENSP00000430829
Pharos - Targets
P15692
ZINC - Predictions - Purchasable
VEGFA_HUMAN
Orphanet
25029
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35968 KDR
4
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.86
6
UniProt:P17948 FLT1
1
VEGFR1 [plasma membrane]
(R-HSA-3004464)
0.761
4
UniProt:P15692 VEGFA
2
VEGFA [platelet alpha granule lumen]
(R-HSA-3132764)
VEGFA [extracellular region]
(R-HSA-2975974)
0.719
10
UniProt:O14786 NRP1
1
NRP1 [plasma membrane]
(R-HSA-3008773)
0.697
4
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