Reactome | VEGFA [extracellular region]

VEGFA [extracellular region]

Stable Identifier

R-HSA-2975974

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Vascular endothelial growth factor A, VEGFA_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
11731620	New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation Huez, I, Bornes, S, Bresson, D, Créancier, L, Prats, H	Mol Endocrinol	2001
11563986	A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon Tee, MK, Jaffe, RB	Biochem J	2001

External Reference Information

External Reference

UniProt:P15692 VEGFA

Gene Names

VEGFA, VEGF

Chain

chain:1-395, chain:1-, chain:-395

Reference Genes

BioGPS Gene:7422 VEGFA

COSMIC (genes):VEGFA VEGFA

CTD Gene:7422 VEGFA

dbSNP Gene:7422 VEGFA

ENSEMBL:ENSG00000112715 VEGFA

HGNC:12680 VEGFA

KEGG:hsa:7422 VEGFA

Monarch:7422 VEGFA

NCBI Gene:7422 VEGFA

OMIM:192240 VEGFA

UCSC:P15692 VEGFA

Reference Transcript

Participates

as a member of

as an output of

as a component of

VEGFA dimer [extracellular region] (Homo sapiens)

Other forms of this molecule

VEGFA [platelet alpha granule lumen]

Inferred To

vegfaa [extracellular region] (Danio rerio)

Vegfa [extracellular region] (Mus musculus)

Vegfa [extracellular region] (Rattus norvegicus)

vegfa [extracellular region] (Xenopus tropicalis)

VEGFA [extracellular region] (Bos taurus)

VEGFA [extracellular region] (Canis familiaris)

VEGFA [extracellular region] (Gallus gallus)

VEGFA [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001165101.1, NP_001165100.1, NP_001273973.1, NP_001165096.1, NP_001165097.1, NP_001020537.2, NP_001028928.1, NP_001020540.2, NP_001020539.2, NP_001020538.2, NP_001191313.1, NP_001165098.1, NP_001165099.1, NP_001191314.1, NP_001020541.2, NP_003367.4, NP_001165094.1, NP_001165095.1, NP_001165093.1, NP_001303939.1

OpenTargets

ENSG00000112715

ENSEMBL

ENST00000518824, ENSP00000500082, ENST00000520948, ENST00000457104, ENSP00000361125, ENSP00000430829, ENSP00000430002, ENSP00000361148, ENSP00000429643, ENST00000372064, ENSP00000429008, ENST00000372067, ENST00000523125, ENSP00000361134, ENSP00000389864, ENSP00000409911, ENSP00000421561, ENST00000672860, ENSP00000317598, ENSP00000430479, ENSP00000361137, ENST00000482630, ENSP00000428321, ENST00000372077, ENSP00000388663, ENST00000372055, ENSG00000112715, ENST00000523950, ENST00000417285, ENST00000324450, ENST00000413642, ENST00000523873, ENST00000518689

ZINC - Substances

VEGFA_HUMAN

ZINC - Biogenic

VEGFA_HUMAN

ZINC target

P15692

PRO

P15692

GlyGen

P15692

PDB

4ZFF, 6BFT, 5FV2, 5HHC, 5HHD, 1MKG, 8UWZ, 1MKK, 1VPF, 5O4E, 6ZCD, 4GLS, 4GLN, 6V7K, 6Z3F, 7LL8, 1QTY, 1FLT, 7KEZ, 1TZI, 3S1B, 6ZBR, 3S1K, 1VPP, 4QAF, 2FJG, 1VGH, 2FJH, 6Z13, 3V2A, 9JU1, 5DN2, 9KKU, 5FV1, 7KF0, 1KAT, 1BJ1, 3QTK, 7KF1, 3P9W, 3BDY, 2VGH, 6D3O, 1CZ8, 4WPB, 2VPF, 7LL9, 6ZFL, 5T89, 1TZH, 4DEQ, 6T9D, 2QR0, 1KMX, 4KZN, 1MJV

ZINC - Metabolites

VEGFA_HUMAN

GeneCards

VEGFA

HPA

ENSG00000112715-VEGFA

Pharos - Targets

P15692

ZINC - Predictions - Purchasable

VEGFA_HUMAN

HMDB Protein

HMDBP02130

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17948 FLT1	1	VEGFR1 [plasma membrane] (R-HSA-3004464)	0.819	5
UniProt:P35968 KDR	5	p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103) VEGFR2 [plasma membrane] (R-HSA-195382) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636)	0.808	5
UniProt:O14786 NRP1	1	NRP1 [plasma membrane] (R-HSA-3008773)	0.77	5
UniProt:P15692 VEGFA	2	VEGFA [extracellular region] (R-HSA-2975974) VEGFA [platelet alpha granule lumen] (R-HSA-3132764)	0.719	10
UniProt:P49765 VEGFB	2	VEGFB [platelet alpha granule lumen] (R-HSA-3132756) VEGFB [extracellular region] (R-HSA-2975973)	0.483	2

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