Reactome | PPM1B [cytosol]

PPM1B [cytosol]

Stable Identifier

R-HSA-1169375

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP2CB, Protein phosphatase 1B, PPM1B_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75688 PPM1B

Gene Names

PPM1B, PP2CB

Chain

initiator methionine:1, chain:2-479

Reference Genes

BioGPS Gene:5495 PPM1B

COSMIC - genes:PPM1B PPM1B

CTD Gene:5495 PPM1B

dbSNP Gene:5495 PPM1B

ENSEMBL:ENSG00000138032 PPM1B

HGNC:9276 PPM1B

KEGG:hsa:5495 PPM1B

Monarch:5495 PPM1B

NCBI Gene:5495 PPM1B

OMIM:603770 PPM1B

UCSC:O75688 PPM1B

Reference Transcript

Participates

as a component of

ISGylated PP2CB [cytosol] (Homo sapiens)

as an input of

ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)

Other forms of this molecule

PPM1B(2-282)-ALK(1058-1620) fusion [cytosol]

PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol]

Inferred To

PPM1B [cytosol] (Bos taurus)

PPM1B [cytosol] (Caenorhabditis elegans)

PPM1B [cytosol] (Mus musculus)

PPM1B [cytosol] (Rattus norvegicus)

PPM1B [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_047300792.1, NP_001028729.1, XP_054198656.1, XP_054198658.1, XP_047300791.1, NP_002697.1, NP_808908.1, NP_808907.1

ZINC - World Drugs

PPM1B_HUMAN

OpenTargets

ENSG00000138032

ENSEMBL

ENST00000282412, ENST00000409432, ENSP00000282412, ENSG00000138032, ENSP00000387287, ENST00000345249, ENSP00000367813, ENST00000378551, ENSP00000326089

ZINC - Substances

PPM1B_HUMAN

ZINC - Biogenic

PPM1B_HUMAN

ZINC target

O75688

PRO

O75688

PDB

2P8E

ZINC - Metabolites

PPM1B_HUMAN

HPA

ENSG00000138032-PPM1B

GeneCards

PPM1B

Pharos - Targets

O75688

Orphanet

PPM1B

ZINC - Predictions - Purchasable

PPM1B_HUMAN

HMDB Protein

HMDBP08793

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.604	4
UniProt:P05161 ISG15	4	ISG15 [cytosol] (R-HSA-936552) K168-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653744) K164-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653745) ISG15 [nucleoplasm] (R-HSA-5653665)	0.558	2
UniProt:P21860 ERBB3			0.553	2
UniProt:P15151 PVR	1	PVR [plasma membrane] (R-HSA-420600)	0.527	3
UniProt:Q9BUH6 PAXX			0.527	2
UniProt:Q9BV44 THUM3			0.527	3
UniProt:Q49MI3 CERKL			0.527	3
UniProt:Q9H293 IL25	1	IL25 [extracellular region] (R-HSA-447101)	0.527	2
UniProt:Q86XA9 HTR5A			0.527	2
UniProt:Q14392 LRC32			0.527	2
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	4
UniProt:Q8IUH3 RBM45			0.462	2

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