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PPM1B [cytosol]
Stable Identifier
R-HSA-1169375
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PP2CB, Protein phosphatase 1B, PPM1B_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)
ISGylated PP2CB [cytosol] (Homo sapiens)
PPM1B [cytosol] (Homo sapiens)
PPM1B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75688 PPM1B
Gene Names
PPM1B, PP2CB
Chain
initiator methionine:, chain:2-479
Reference Genes
BioGPS Gene:5495 PPM1B
COSMIC (genes):PPM1B PPM1B
CTD Gene:5495 PPM1B
dbSNP Gene:5495 PPM1B
ENSEMBL:ENSG00000138032 PPM1B
ENSEMBL_homo_sapiens_GENE:ENSG00000138032.21 PPM1B
HGNC:9276 PPM1B
KEGG Gene (Homo sapiens):5495 PPM1B
Monarch:5495 PPM1B
NCBI Gene:5495 PPM1B
OMIM:603770 PPM1B
UCSC:O75688 PPM1B
Reference Transcript
RefSeq:NM_177968.3 PPM1B
RefSeq:NM_002706.5 PPM1B
RefSeq:NM_001033557.2 PPM1B
RefSeq:NM_177969.3 PPM1B
Other Identifiers
11719712_at
11719713_a_at
11719714_at
11725259_s_at
11735019_a_at
16879581
209296_PM_at
209296_at
213225_PM_at
213225_at
2479644
2479645
2479646
2479648
2479652
2479660
2479661
2479665
2479666
2479667
2479668
2479669
2479670
2479671
32665_at
53139_at
5495
8041713
A_14_P115943
A_14_P135663
A_23_P209269
A_23_P398073
A_33_P3296352
A_33_P3407742
A_33_P3407746
GE55164
GO:0000287
GO:0003824
GO:0004721
GO:0004722
GO:0005515
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0006470
GO:0006499
GO:0016020
GO:0016787
GO:0017018
GO:0023052
GO:0030145
GO:0032688
GO:0035970
GO:0036211
GO:0043124
GO:0043169
GO:0043226
GO:0046872
GO:0050687
GO:0090263
GO:0098542
GO:0140096
GO:1901223
HMNXSV003008526
Hs.5687.1.S2_3p_at
ILMN_1716862
ILMN_1727138
ILMN_1796085
ILMN_2377210
PH_hs_0025060
g12239323_3p_at
Participates
as a component of
ISGylated PP2CB [cytosol] (Homo sapiens)
as an input of
ISGylation of protein phosphatase 1 beta (PP2CB) (Homo sapiens)
Other forms of this molecule
PPM1B(2-282)-ALK(1058-1620) fusion [cytosol]
PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol]
Inferred To
alph [cytosol]
(Drosophila melanogaster)
tap-1 [cytosol]
(Caenorhabditis elegans)
Nil [cytosol]
(Drosophila melanogaster)
PPM1B [cytosol]
(Bos taurus)
PPM1B [cytosol]
(Caenorhabditis elegans)
PPM1B [cytosol]
(Mus musculus)
PPM1B [cytosol]
(Rattus norvegicus)
PPM1B [cytosol]
(Sus scrofa)
Homologues of PPM1B [cytosol]
(Caenorhabditis elegans)
Homologues of PPM1B [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_808907.1
,
NP_001028729.1
,
NP_808908.1
,
NP_002697.1
ZINC - World Drugs
PPM1B_HUMAN
OpenTargets
ENSG00000138032
ZINC - Substances
PPM1B_HUMAN
ZINC target
O75688
ZINC - Biogenic
PPM1B_HUMAN
PRO
O75688
PDB
2P8E
ZINC - Metabolites
PPM1B_HUMAN
HPA
ENSG00000138032-PPM1B
GeneCards
O75688
Ensembl
ENSP00000367813
,
ENST00000345249
,
ENST00000282412
,
ENST00000378551
,
ENSP00000326089
,
ENSP00000387287
,
ENST00000409432
,
ENSP00000282412
,
ENSG00000138032
Pharos - Targets
O75688
Orphanet
19496
ZINC - Predictions - Purchasable
PPM1B_HUMAN
HMDB Protein
HMDBP08793
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.604
4
UniProt:P05161 ISG15
4
ISG15 [nucleoplasm]
(R-HSA-5653665)
K164-PCNA-G157-ISG15 [nucleoplasm]
(R-HSA-5653745)
ISG15 [cytosol]
(R-HSA-936552)
K168-PCNA-G157-ISG15 [nucleoplasm]
(R-HSA-5653744)
0.558
2
UniProt:P21860 ERBB3
0.553
2
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
4
UniProt:Q8IUH3 RBM45
0.462
2
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