PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9713479
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein phosphatase 1B ecNumber3.1.3.16/ecNumber, PPM1B_HUMAN
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
27245569 Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization

Ali, SM, Hensing, T, Schrock, AB, Allen, J, Sanford, E, Gowen, K, Kulkarni, A, He, J, Suh, JH, Lipson, D, Elvin, JA, Yelensky, R, Chalmers, Z, Chmielecki, J, Peled, N, Klempner, SJ, Firozvi, K, Frampton, GM, Molina, JR, Menon, S, Brahmer, JR, MacMahon, H, Nowak, J, Ou, SH, Zauderer, M, Ladanyi, M, Zakowski, M, Fischbach, N, Ross, JS, Stephens, PJ, Miller, VA, Wakelee, H, Ganesan, S, Salgia, R

Oncologist 2016
External Reference Information
External Reference
UniProt:O75688 PPM1B
Gene Names
PPM1B, PP2CB
Chain
initiator methionine:1, chain:2-479
Reference Genes
BioGPS Gene:5495 PPM1B
COSMIC (genes):PPM1B PPM1B
CTD Gene:5495 PPM1B
dbSNP Gene:5495 PPM1B
ENSEMBL:ENSG00000138032 PPM1B
HGNC:9276 PPM1B
KEGG:hsa:5495 PPM1B
Monarch:5495 PPM1B
NCBI Gene:5495 PPM1B
OMIM:603770 PPM1B
UCSC:O75688 PPM1B
Reference Transcript
Participates
as a component of
Other forms of this molecule
PPM1B [cytosol]
PPM1B(2-282)-ALK(1058-1620) fusion [cytosol]
Modified Residues
Name
Insertion of residues 1058 to 1620 at 283 from UniProt:Q9UM73 ALK
Coordinate
283
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1359
Coordinate
1359
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ENSEMBL
Mondo
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Metabolites
IntEnz
HPA
GeneCards
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (12)
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