ADAM17 cleavage of Ghr

Stable Identifier
R-MMU-1168790
Type
Reaction [transition]
Species
Mus musculus
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ADAM17 cleavage of Ghr
The Growth Hormone Receptor is cleaved by ADAM17 releasing the extracellular region as Growth Hormone Binding Protein (Zhang et al. 2000). The precise site of cleavage is not clear for mouse, but has been characterized in rabbit as between Pro-256 and Phe-257, a site conserved in human (Wang et al. 2002).
Literature References
PubMed ID Title Journal Year
11108241 Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation

Baumann, G, Black, RA, Jiang, J, Zhang, Y, Frank, SJ

Endocrinology 2000
12403792 Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site

Lu, C, Paxton, RJ, Gerhart, M, Baumann, G, Black, RA, Jiang, J, Huang, Y, He, K, Yang, S, Menon, RK, Frank, SJ, Wang, X

J Biol Chem 2002
Participants
Input
Output
Catalyst Activity

metalloendopeptidase activity of Adam17 [extracellular region]

Physical Entity
Adam17 [extracellular region] (Mus musculus)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Metalloprotease cleavage of GHR (Homo sapiens)
Authored
Jupe, S  (2010-10-14)
Reviewed
Herington, AC  (2011-06-13)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2011-01-07)
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