Reactome | TGFB3 [extracellular region]

TGFB3 [extracellular region]

Stable Identifier

R-HSA-114707

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

TGF-beta-3, Transforming growth factor beta 3 precursor

Locations in the PathwayBrowser

Expand all

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
    - Platelet degranulation (Homo sapiens)
      - Exocytosis of platelet alpha granule contents (Homo sapiens)
        
        Platelet alpha granule contents [extracellular region] (Homo sapiens)
        
        TGF beta [extracellular region] (Homo sapiens)
        
        TGFB3 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10600 TGFB3

Gene Names

TGFB3

Chain

signal peptide:1-23, chain:24-300, chain:301-412

Reference Genes

BioGPS Gene:7043 TGFB3

COSMIC (genes):TGFB3 TGFB3

CTD Gene:7043 TGFB3

dbSNP Gene:7043 TGFB3

ENSEMBL:ENSG00000119699 TGFB3

ENSEMBL:ENSG00000119699.8 TGFB3

HGNC:11769 TGFB3

KEGG Gene (Homo sapiens):7043 TGFB3

Monarch:7043 TGFB3

NCBI Gene:7043 TGFB3

OMIM:190230 TGFB3

UCSC:P10600 TGFB3

Reference Transcript

Other Identifiers

11727296_s_at

11727297_a_at

11751400_a_at

1555540_PM_at

1555540_at

16794980

1734_at

1735_g_at

1767_s_at

209747_PM_at

209747_at

3572518

3572519

3572524

3572527

3572528

3572529

3572533

3572534

3572536

3572537

3572538

3572539

3572540

3572541

3572542

3572543

3572544

7043

7980316

A_23_P88404

A_24_P373096

GE59720

GE83908

GO:0001666

GO:0001701

GO:0002376

GO:0005114

GO:0005125

GO:0005160

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006351

GO:0006355

GO:0007010

GO:0007165

GO:0007179

GO:0007435

GO:0007565

GO:0008083

GO:0008284

GO:0008285

GO:0009986

GO:0010718

GO:0010862

GO:0010936

GO:0012501

GO:0022414

GO:0023052

GO:0030141

GO:0030154

GO:0030312

GO:0030315

GO:0030509

GO:0030512

GO:0030879

GO:0031012

GO:0031093

GO:0031410

GO:0032570

GO:0032967

GO:0034330

GO:0034616

GO:0034713

GO:0034714

GO:0036211

GO:0042127

GO:0042476

GO:0042704

GO:0042802

GO:0043025

GO:0043065

GO:0043226

GO:0043231

GO:0043410

GO:0043524

GO:0043627

GO:0044877

GO:0045216

GO:0045893

GO:0045944

GO:0048018

GO:0048286

GO:0048565

GO:0048702

GO:0048839

GO:0048856

GO:0050431

GO:0050714

GO:0051491

GO:0051496

GO:0051781

GO:0060325

GO:0060364

GO:0060391

GO:0060395

GO:0062009

GO:0062023

GO:0070483

GO:0098772

GO:1904706

GO:1905075

HMNXSV003009357

HMNXSV003053119

Hs2.2025.2.A1_3p_s_at

J03241_s_at

M60556_rna2_at

PH_hs_0000271

TC14001326.hg

X14885_rna1_s_at

g339551_3p_at

Participates

as a member of

TGF beta [extracellular region] (Homo sapiens)

as a component of

TGFB3:LAP3 [extracellular region] (Homo sapiens)

Other forms of this molecule

TGFB3 [platelet alpha granule lumen]

TGFB3(21-300) [extracellular region]

Inferred To

mav [extracellular region] (Drosophila melanogaster)

wu:fc78g09 [extracellular region] (Danio rerio)

Homologues of TGFB3 [extracellular region] (Caenorhabditis elegans)

Homologues of TGFB3 [extracellular region] (Drosophila melanogaster)

Homologues of TGFB3 [extracellular region] (Sus scrofa)

dbl-1 [extracellular region] (Caenorhabditis elegans)

Tgfb3 [extracellular region] (Mus musculus)

Tgfb3 [extracellular region] (Rattus norvegicus)

tig-2 [extracellular region] (Caenorhabditis elegans)

tig-3 [extracellular region] (Caenorhabditis elegans)

gbb [extracellular region] (Drosophila melanogaster)

TGFB3 [extracellular region] (Bos taurus)

TGFB3 [extracellular region] (Canis familiaris)

TGFB3 [extracellular region] (Gallus gallus)

TGFB3 [extracellular region] (Sus scrofa)

dpp [extracellular region] (Drosophila melanogaster)

scw [extracellular region] (Drosophila melanogaster)

unc-129 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001316868.1, NP_003230.1, NP_001316867.1

OpenTargets

ENSG00000119699

GeneCards

P10600

HPA

ENSG00000119699-TGFB3

Ensembl

ENSP00000502685, ENSP00000238682, ENSP00000451110, ENSG00000119699, ENST00000556674, ENST00000556285, ENST00000238682

PRO

P10600

Pharos - Targets

P10600

Orphanet

15608

HMDB Protein

HMDBP14474

PDB

1TGJ, 4UM9, 1TGK, 1KTZ, 2PJY, 3EO1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.765	8