Reactome | Cleavage of Procaspase-7 by the apoptosome

Cleavage of Procaspase-7 by the apoptosome

Stable Identifier

R-HSA-114261

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Apoptotic factor-mediated response (Homo sapiens)
      - Cytochrome c-mediated apoptotic response (Homo sapiens)
        
        Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)
        
        Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)

General

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Cleavage of Procaspase-7 by the apoptosome

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Caspases-3 and -7 are directly cleaved downstream of caspase-9 in the cytochrome c/Apaf-1-inducible caspase cascade (Slee et al., 1999).

Literature References

PubMed ID	Title	Journal	Year
12824163	Human caspase-7 activity and regulation by its N-terminal peptide Denault, JB, Salvesen, GS	J. Biol. Chem.	2003
11701129	Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding Chai, J, Wu, Q, Shiozaki, E, Srinivasula, SM, Alnemri, ES, Shi, Y	Cell	2001
11752425	Structural basis for the activation of human procaspase-7 Riedl, SJ, Fuentes-Prior, P, Renatus, M, Kairies, N, Krapp, S, Huber, R, Salvesen, GS, Bode, W	Proc. Natl. Acad. Sci. U.S.A.	2001
16916640	Engineered hybrid dimers: tracking the activation pathway of caspase-7 Denault, JB, Békés, M, Scott, FL, Sexton, KM, Bogyo, M, Salvesen, GS	Mol. Cell	2006
9922454	Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner Slee, EA, Harte, MT, Kluck, RM, Wolf, BB, Casiano, CA, Newmeyer, DD, Wang, HG, Reed, JC, Nicholson, DW, Alnemri, ES, Green, DR, Martin, SJ	J Cell Biol	1999