Cleavage of Procaspase-7 by the apoptosome

Stable Identifier
R-HSA-114261
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Cleavage of Procaspase-7 by the apoptosome
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Caspases-3 and -7 are directly cleaved downstream of caspase-9 in the cytochrome c/Apaf-1-inducible caspase cascade (Slee et al., 1999).
Literature References
PubMed ID Title Journal Year
11701129 Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding

Chai, J, Wu, Q, Shiozaki, E, Srinivasula, SM, Alnemri, ES, Shi, Y

Cell 2001
12824163 Human caspase-7 activity and regulation by its N-terminal peptide

Denault, JB, Salvesen, GS

J. Biol. Chem. 2003
11752425 Structural basis for the activation of human procaspase-7

Riedl, SJ, Fuentes-Prior, P, Renatus, M, Kairies, N, Krapp, S, Huber, R, Salvesen, GS, Bode, W

Proc. Natl. Acad. Sci. U.S.A. 2001
16916640 Engineered hybrid dimers: tracking the activation pathway of caspase-7

Denault, JB, Békés, M, Scott, FL, Sexton, KM, Bogyo, M, Salvesen, GS

Mol. Cell 2006
9922454 Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

Slee, EA, Harte, MT, Kluck, RM, Wolf, BB, Casiano, CA, Newmeyer, DD, Wang, HG, Reed, JC, Nicholson, DW, Alnemri, ES, Green, DR, Martin, SJ

J Cell Biol 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cysteine-type endopeptidase activity of Apoptosome [cytosol]

Physical Entity
Apoptosome [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
This event is regulated
Negatively by
Regulator
XIAP [cytosol] (Homo sapiens)
Orthologous Events
Cleavage of Procaspase-7 by the apoptosome (Bos taurus)
Cleavage of Procaspase-7 by the apoptosome (Canis familiaris)
Cleavage of Procaspase-7 by the apoptosome (Danio rerio)
Cleavage of Procaspase-7 by the apoptosome (Drosophila melanogaster)
Cleavage of Procaspase-7 by the apoptosome (Gallus gallus)
Cleavage of Procaspase-7 by the apoptosome (Mus musculus)
Cleavage of Procaspase-7 by the apoptosome (Rattus norvegicus)
Cleavage of Procaspase-7 by the apoptosome (Sus scrofa)
Cleavage of Procaspase-7 by the apoptosome (Xenopus tropicalis)
Authored
Alnemri, E  (2004-02-17)
Reviewed
Matthews, L  (2018-09-25)
Created
Alnemri, E  (2004-02-17)
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