Cleavage of Procaspase-7 by the apoptosome

Stable Identifier
Reaction [transition]
Homo sapiens
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Caspases-3 and -7 are directly cleaved downstream of caspase-9 in the cytochrome c/Apaf-1-inducible caspase cascade (Slee et al., 1999).
Literature References
PubMed ID Title Journal Year
11701129 Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding

Alnemri, ES, Chai, J, Shi, Y, Srinivasula, SM, Shiozaki, E, Wu, Q

Cell 2001
12824163 Human caspase-7 activity and regulation by its N-terminal peptide

Denault, JB, Salvesen, GS

J. Biol. Chem. 2003
11752425 Structural basis for the activation of human procaspase-7

Kairies, N, Fuentes-Prior, P, Riedl, SJ, Bode, W, Huber, R, Salvesen, GS, Renatus, M, Krapp, S

Proc. Natl. Acad. Sci. U.S.A. 2001
16916640 Engineered hybrid dimers: tracking the activation pathway of caspase-7

Békés, M, Sexton, KM, Denault, JB, Bogyo, M, Scott, FL, Salvesen, GS

Mol. Cell 2006
9922454 Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

Wolf, BB, Reed, JC, Kluck, RM, Newmeyer, DD, Wang, HG, Casiano, CA, Harte, MT, Slee, EA, Martin, SJ, Green, DR, Nicholson, DW, Alnemri, ES

J Cell Biol 1999
Catalyst Activity

cysteine-type endopeptidase activity of Apoptosome [cytosol]

This event is regulated
Negatively by
Orthologous Events
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