Activation of caspases through apoptosome-mediated cleavage

Stable Identifier
R-HSA-111459
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of caspases through apoptosome-mediated cleavage
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Procaspase-3 and 7 are cleaved by the apoptosome.

Literature References
PubMed ID Title Journal Year
9390557 Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

Srinivasula, SM, Wang, X, Budihardjo, I, Nijhawan, D, Li, P, Alnemri, ES

Cell 1997
9922454 Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

Wolf, BB, Reed, JC, Kluck, RM, Newmeyer, DD, Wang, HG, Casiano, CA, Harte, MT, Slee, EA, Martin, SJ, Green, DR, Nicholson, DW, Alnemri, ES

J Cell Biol 1999
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Event Information
Go Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (0008635)
Orthologous Events
Activation of caspases through apoptosome-mediated cleavage (Bos taurus)
Activation of caspases through apoptosome-mediated cleavage (Canis familiaris)
Activation of caspases through apoptosome-mediated cleavage (Danio rerio)
Activation of caspases through apoptosome-mediated cleavage (Gallus gallus)
Activation of caspases through apoptosome-mediated cleavage (Mus musculus)
Activation of caspases through apoptosome-mediated cleavage (Rattus norvegicus)
Activation of caspases through apoptosome-mediated cleavage (Sus scrofa)
Activation of caspases through apoptosome-mediated cleavage (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Alnemri, E  (2004-02-17)
Reviewed
Matthews, L  (2018-09-25)
Created
Alnemri, E  (2004-02-17)
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