Activation of caspases through apoptosome-mediated cleavage

Stable Identifier
R-HSA-111459
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
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Activation of caspases through apoptosome-mediated cleavage
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Procaspase-3 and 7 are cleaved by the apoptosome.

Literature References
PubMed ID Title Journal Year
9922454 Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

Slee, EA, Harte, MT, Kluck, RM, Wolf, BB, Casiano, CA, Newmeyer, DD, Wang, HG, Reed, JC, Nicholson, DW, Alnemri, ES, Green, DR, Martin, SJ

J Cell Biol 1999
9390557 Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

Li, P, Nijhawan, D, Budihardjo, I, Srinivasula, SM, Alnemri, ES, Wang, X

Cell 1997
Participants
Events
Participant Of
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Event Information
Go Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (0008635)
Orthologous Events
Activation of caspases through apoptosome-mediated cleavage (Danio rerio)
Activation of caspases through apoptosome-mediated cleavage (Drosophila melanogaster)
Activation of caspases through apoptosome-mediated cleavage (Gallus gallus)
Activation of caspases through apoptosome-mediated cleavage (Mus musculus)
Activation of caspases through apoptosome-mediated cleavage (Rattus norvegicus)
Activation of caspases through apoptosome-mediated cleavage (Sus scrofa)
Cross References
BioModels Database
Authored
Alnemri, E  (2004-02-17)
Reviewed
Matthews, L  (2018-09-25)
Created
Alnemri, E  (2004-02-17)
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