Caspase-7

Stable Identifier
R-HSA-141643
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
2x(CASP7(24-198):CASP7(207-303))
Locations in the PathwayBrowser
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Summation

CASP7 heterotetramer consists of two anti-parallel arranged CASP7 heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.

Literature References
PubMed ID Title Journal Year
11752425 Structural basis for the activation of human procaspase-7

Riedl, SJ, Fuentes-Prior, P, Renatus, M, Kairies, N, Krapp, S, Huber, R, Salvesen, GS, Bode, W

Proc. Natl. Acad. Sci. U.S.A. 2001
11701129 Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding

Chai, J, Wu, Q, Shiozaki, E, Srinivasula, SM, Alnemri, ES, Shi, Y

Cell 2001
23650375 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation

Thomsen, ND, Koerber, JT, Wells, JA

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
components
Participant Of
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input
output
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Inferred To
Caspase-7 [cytosol] (Bos taurus)
Caspase-7 [cytosol] (Canis familiaris)
Caspase-7 [cytosol] (Danio rerio)
Caspase-7 [cytosol] (Drosophila melanogaster)
Caspase-7 [cytosol] (Gallus gallus)
Caspase-7 [cytosol] (Mus musculus)
Caspase-7 [cytosol] (Rattus norvegicus)
Caspase-7 [cytosol] (Sus scrofa)
Caspase-7 [cytosol] (Taeniopygia guttata)
Caspase-7 [cytosol] (Xenopus tropicalis)