Reactome | PLC beta mediated events

PLC beta mediated events

Stable Identifier

R-HSA-112043

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, endoplasmic reticulum membrane, endoplasmic reticulum lumen, nucleoplasm, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)

General

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The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. PLC hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions.

Literature References

PubMed ID	Title	Journal	Year
9218123	G proteins and opioid receptor-mediated signalling Pasternak, GW, Standifer, KM	Cell Signal	1997
16183910	Mammalian G proteins and their cell type specific functions Offermanns, S, Wettschureck, N	Physiol Rev	2005
1335363	Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits Birnbaumer, L	Cell	1992