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ORO [cytosol]
Stable Identifier
R-ALL-76632
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
orotate, uracil-6-carboxylic acid, orotic acid
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of nucleotides (Bos taurus)
Nucleotide biosynthesis (Bos taurus)
Pyrimidine biosynthesis (Bos taurus)
DHODH:FMN oxidises (S)-DHO to orotate (Bos taurus)
ORO [cytosol]
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Bos taurus)
ORO [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide biosynthesis (Caenorhabditis elegans)
Pyrimidine biosynthesis (Caenorhabditis elegans)
DHODH:FMN oxidises (S)-DHO to orotate (Caenorhabditis elegans)
ORO [cytosol]
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Caenorhabditis elegans)
ORO [cytosol]
Metabolism (Canis familiaris)
Metabolism of nucleotides (Canis familiaris)
Nucleotide biosynthesis (Canis familiaris)
Pyrimidine biosynthesis (Canis familiaris)
DHODH:FMN oxidises (S)-DHO to orotate (Canis familiaris)
ORO [cytosol]
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Canis familiaris)
ORO [cytosol]
Metabolism (Danio rerio)
Metabolism of nucleotides (Danio rerio)
Nucleotide biosynthesis (Danio rerio)
Pyrimidine biosynthesis (Danio rerio)
DHODH:FMN oxidises (S)-DHO to orotate (Danio rerio)
ORO [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of nucleotides (Dictyostelium discoideum)
Nucleotide biosynthesis (Dictyostelium discoideum)
Pyrimidine biosynthesis (Dictyostelium discoideum)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)
ORO [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide biosynthesis (Drosophila melanogaster)
Pyrimidine biosynthesis (Drosophila melanogaster)
DHODH:FMN oxidises (S)-DHO to orotate (Drosophila melanogaster)
ORO [cytosol]
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)
ORO [cytosol]
Metabolism (Gallus gallus)
Nucleotide metabolism (Gallus gallus)
Pyrimidine metabolism: de novo synthesis of UMP (Gallus gallus)
(S)-dihydroorotate + ubiquinone => orotate + ubiquinol (Gallus gallus)
ORO [cytosol]
orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)
ORO [cytosol]
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide biosynthesis (Homo sapiens)
Pyrimidine biosynthesis (Homo sapiens)
DHODH:FMN oxidises (S)-DHO to orotate (Homo sapiens)
ORO [cytosol]
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)
ORO [cytosol]
Metabolism (Mus musculus)
Metabolism of nucleotides (Mus musculus)
Nucleotide biosynthesis (Mus musculus)
Pyrimidine biosynthesis (Mus musculus)
DHODH:FMN oxidises (S)-DHO to orotate (Mus musculus)
ORO [cytosol]
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)
ORO [cytosol]
Metabolism (Plasmodium falciparum)
Metabolism of nucleotides (Plasmodium falciparum)
Nucleotide biosynthesis (Plasmodium falciparum)
Pyrimidine biosynthesis (Plasmodium falciparum)
DHODH:FMN oxidises (S)-DHO to orotate (Plasmodium falciparum)
ORO [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of nucleotides (Rattus norvegicus)
Nucleotide biosynthesis (Rattus norvegicus)
Pyrimidine biosynthesis (Rattus norvegicus)
DHODH:FMN oxidises (S)-DHO to orotate (Rattus norvegicus)
ORO [cytosol]
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)
ORO [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of nucleotides (Schizosaccharomyces pombe)
Nucleotide biosynthesis (Schizosaccharomyces pombe)
Pyrimidine biosynthesis (Schizosaccharomyces pombe)
DHODH:FMN oxidises (S)-DHO to orotate (Schizosaccharomyces pombe)
ORO [cytosol]
Metabolism (Sus scrofa)
Metabolism of nucleotides (Sus scrofa)
Nucleotide biosynthesis (Sus scrofa)
Pyrimidine biosynthesis (Sus scrofa)
DHODH:FMN oxidises (S)-DHO to orotate (Sus scrofa)
ORO [cytosol]
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)
ORO [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of nucleotides (Xenopus tropicalis)
Nucleotide biosynthesis (Xenopus tropicalis)
Pyrimidine biosynthesis (Xenopus tropicalis)
DHODH:FMN oxidises (S)-DHO to orotate (Xenopus tropicalis)
ORO [cytosol]
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Xenopus tropicalis)
ORO [cytosol]
External Reference Information
External Reference
orotate [ChEBI:30839]
Participates
as an output of
(S)-dihydroorotate + ubiquinone => orotate + ubiquinol (Gallus gallus)
DHODH:FMN oxidises (S)-DHO to orotate (Plasmodium falciparum)
DHODH:FMN oxidises (S)-DHO to orotate (Schizosaccharomyces pombe)
DHODH:FMN oxidises (S)-DHO to orotate (Caenorhabditis elegans)
DHODH:FMN oxidises (S)-DHO to orotate (Drosophila melanogaster)
DHODH:FMN oxidises (S)-DHO to orotate (Gallus gallus)
DHODH:FMN oxidises (S)-DHO to orotate (Xenopus tropicalis)
DHODH:FMN oxidises (S)-DHO to orotate (Danio rerio)
DHODH:FMN oxidises (S)-DHO to orotate (Sus scrofa)
DHODH:FMN oxidises (S)-DHO to orotate (Bos taurus)
DHODH:FMN oxidises (S)-DHO to orotate (Canis familiaris)
DHODH:FMN oxidises (S)-DHO to orotate (Rattus norvegicus)
DHODH:FMN oxidises (S)-DHO to orotate (Mus musculus)
DHODH:FMN oxidises (S)-DHO to orotate (Homo sapiens)
as an input of
orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Caenorhabditis elegans)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Gallus gallus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Xenopus tropicalis)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Bos taurus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Canis familiaris)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)
Cross References
COMPOUND
C00295
ZINC
000001408068
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