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About
What is Reactome ?
News
Team
Scientific Advisory Board
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Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
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Analysis Gene Expression
Species Comparison
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Diseases
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PRPP [cytosol]
Stable Identifier
R-ALL-73566
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
5-phospho-alpha-D-ribose 1-diphosphate, 5-O-phosphono-alpha-D-ribofuranosyl diphosphate, 5-Phosphoribosyl diphosphate, 5-Phosphoribosyl 1-pyrophosphate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Drug ADME (Bos taurus)
Azathioprine ADME (Bos taurus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)
PRPP [cytosol]
Metabolism (Bos taurus)
Metabolism of carbohydrates (Bos taurus)
Pentose phosphate pathway (Bos taurus)
5-Phosphoribose 1-diphosphate biosynthesis (Bos taurus)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Bos taurus)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Bos taurus)
PRPP [cytosol]
Metabolism of nucleotides (Bos taurus)
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
PRPP [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Bos taurus)
PRPP [cytosol]
Pyrimidine biosynthesis (Bos taurus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Bos taurus)
PRPP [cytosol]
Nucleotide salvage (Bos taurus)
Purine salvage (Bos taurus)
APRT catalyzes the conversion of adenine to AMP (Bos taurus)
PRPP [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Bos taurus)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Nicotinate metabolism (Bos taurus)
Nicotinamide salvaging (Bos taurus)
NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)
PRPP [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)
PRPP [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)
PRPP [cytosol]
Drug ADME (Caenorhabditis elegans)
Azathioprine ADME (Caenorhabditis elegans)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)
PRPP [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
PRPP [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Caenorhabditis elegans)
PRPP [cytosol]
Pyrimidine biosynthesis (Caenorhabditis elegans)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Caenorhabditis elegans)
PRPP [cytosol]
Nucleotide salvage (Caenorhabditis elegans)
Purine salvage (Caenorhabditis elegans)
APRT catalyzes the conversion of adenine to AMP (Caenorhabditis elegans)
PRPP [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Nicotinate metabolism (Caenorhabditis elegans)
Nicotinamide salvaging (Caenorhabditis elegans)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)
PRPP [cytosol]
Drug ADME (Canis familiaris)
Azathioprine ADME (Canis familiaris)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)
PRPP [cytosol]
Metabolism (Canis familiaris)
Metabolism of carbohydrates (Canis familiaris)
Pentose phosphate pathway (Canis familiaris)
5-Phosphoribose 1-diphosphate biosynthesis (Canis familiaris)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Canis familiaris)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Canis familiaris)
PRPP [cytosol]
Metabolism of nucleotides (Canis familiaris)
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
PRPP [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Canis familiaris)
PRPP [cytosol]
Pyrimidine biosynthesis (Canis familiaris)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Canis familiaris)
PRPP [cytosol]
Nucleotide salvage (Canis familiaris)
Purine salvage (Canis familiaris)
APRT catalyzes the conversion of adenine to AMP (Canis familiaris)
PRPP [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Canis familiaris)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Nicotinate metabolism (Canis familiaris)
Nicotinamide salvaging (Canis familiaris)
NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)
PRPP [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)
PRPP [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)
PRPP [cytosol]
Drug ADME (Danio rerio)
Azathioprine ADME (Danio rerio)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Danio rerio)
PRPP [cytosol]
Metabolism (Danio rerio)
Metabolism of carbohydrates (Danio rerio)
Pentose phosphate pathway (Danio rerio)
5-Phosphoribose 1-diphosphate biosynthesis (Danio rerio)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Danio rerio)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Danio rerio)
PRPP [cytosol]
Metabolism of nucleotides (Danio rerio)
Nucleotide biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
PRPP [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Danio rerio)
PRPP [cytosol]
Pyrimidine biosynthesis (Danio rerio)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Danio rerio)
PRPP [cytosol]
Nucleotide salvage (Danio rerio)
Purine salvage (Danio rerio)
APRT catalyzes the conversion of adenine to AMP (Danio rerio)
PRPP [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Danio rerio)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Nicotinate metabolism (Danio rerio)
Nicotinamide salvaging (Danio rerio)
NAMPT transfers PRIB to NAM to form NAMN (Danio rerio)
PRPP [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)
PRPP [cytosol]
Drug ADME (Dictyostelium discoideum)
Azathioprine ADME (Dictyostelium discoideum)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Dictyostelium discoideum)
PRPP [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of carbohydrates (Dictyostelium discoideum)
Pentose phosphate pathway (Dictyostelium discoideum)
5-Phosphoribose 1-diphosphate biosynthesis (Dictyostelium discoideum)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Dictyostelium discoideum)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Dictyostelium discoideum)
PRPP [cytosol]
Metabolism of nucleotides (Dictyostelium discoideum)
Nucleotide biosynthesis (Dictyostelium discoideum)
Pyrimidine biosynthesis (Dictyostelium discoideum)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)
PRPP [cytosol]
Nucleotide salvage (Dictyostelium discoideum)
Purine salvage (Dictyostelium discoideum)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Dictyostelium discoideum)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Nicotinate metabolism (Dictyostelium discoideum)
Nicotinamide salvaging (Dictyostelium discoideum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)
PRPP [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)
PRPP [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
PRPP [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Drosophila melanogaster)
PRPP [cytosol]
Pyrimidine biosynthesis (Drosophila melanogaster)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)
PRPP [cytosol]
Nucleotide salvage (Drosophila melanogaster)
Purine salvage (Drosophila melanogaster)
APRT catalyzes the conversion of adenine to AMP (Drosophila melanogaster)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Nicotinate metabolism (Drosophila melanogaster)
Nicotinamide salvaging (Drosophila melanogaster)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)
PRPP [cytosol]
Drug ADME (Gallus gallus)
Azathioprine ADME (Gallus gallus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)
PRPP [cytosol]
Metabolism (Gallus gallus)
Nucleotide metabolism (Gallus gallus)
Purine metabolism (Gallus gallus)
De novo synthesis of IMP (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate (Gallus gallus)
PRPP [cytosol]
Formation of PPAT dimers (Gallus gallus)
PRPP [cytosol]
Formation of PPAT tetramers (Gallus gallus)
PRPP [cytosol]
Pyrimidine metabolism: de novo synthesis of UMP (Gallus gallus)
orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)
PRPP [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of nucleotide metabolism (Homo sapiens)
Nucleotide salvage defects (Homo sapiens)
Defective APRT disrupts adenine salvage (Homo sapiens)
Defective APRT does not convert adenine to AMP (Homo sapiens)
PRPP [cytosol]
Defective HPRT1 disrupts guanine and hypoxanthine salvage (Homo sapiens)
Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP (Homo sapiens)
PRPP [cytosol]
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Homo sapiens)
PRPP [cytosol]
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Pentose phosphate pathway (Homo sapiens)
5-Phosphoribose 1-diphosphate biosynthesis (Homo sapiens)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Homo sapiens)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Homo sapiens)
PRPP [cytosol]
Metabolism of nucleotides (Homo sapiens)
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)
PRPP [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Homo sapiens)
PRPP [cytosol]
Pyrimidine biosynthesis (Homo sapiens)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)
PRPP [cytosol]
Nucleotide salvage (Homo sapiens)
Purine salvage (Homo sapiens)
APRT catalyzes the conversion of adenine to AMP (Homo sapiens)
PRPP [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Homo sapiens)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Nicotinate metabolism (Homo sapiens)
Nicotinamide salvaging (Homo sapiens)
NAMPT transfers PRIB to NAM to form NAMN (Homo sapiens)
PRPP [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)
PRPP [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)
PRPP [cytosol]
Drug ADME (Mus musculus)
Azathioprine ADME (Mus musculus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)
PRPP [cytosol]
Metabolism (Mus musculus)
Metabolism of carbohydrates (Mus musculus)
Pentose phosphate pathway (Mus musculus)
5-Phosphoribose 1-diphosphate biosynthesis (Mus musculus)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Mus musculus)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Mus musculus)
PRPP [cytosol]
Metabolism of nucleotides (Mus musculus)
Nucleotide biosynthesis (Mus musculus)
Purine ribonucleoside monophosphate biosynthesis (Mus musculus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)
PRPP [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Mus musculus)
PRPP [cytosol]
Pyrimidine biosynthesis (Mus musculus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)
PRPP [cytosol]
Nucleotide salvage (Mus musculus)
Purine salvage (Mus musculus)
APRT catalyzes the conversion of adenine to AMP (Mus musculus)
PRPP [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Mus musculus)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Nicotinate metabolism (Mus musculus)
Nicotinamide salvaging (Mus musculus)
NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)
PRPP [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)
PRPP [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)
PRPP [cytosol]
Drug ADME (Plasmodium falciparum)
Azathioprine ADME (Plasmodium falciparum)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Plasmodium falciparum)
PRPP [cytosol]
Metabolism (Plasmodium falciparum)
Metabolism of carbohydrates (Plasmodium falciparum)
Pentose phosphate pathway (Plasmodium falciparum)
5-Phosphoribose 1-diphosphate biosynthesis (Plasmodium falciparum)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Plasmodium falciparum)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Plasmodium falciparum)
PRPP [cytosol]
Metabolism of nucleotides (Plasmodium falciparum)
Nucleotide salvage (Plasmodium falciparum)
Purine salvage (Plasmodium falciparum)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Plasmodium falciparum)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Plasmodium falciparum)
Metabolism of water-soluble vitamins and cofactors (Plasmodium falciparum)
Nicotinate metabolism (Plasmodium falciparum)
Nicotinamide salvaging (Plasmodium falciparum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)
PRPP [cytosol]
Drug ADME (Rattus norvegicus)
Azathioprine ADME (Rattus norvegicus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Rattus norvegicus)
PRPP [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of carbohydrates (Rattus norvegicus)
Pentose phosphate pathway (Rattus norvegicus)
5-Phosphoribose 1-diphosphate biosynthesis (Rattus norvegicus)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Rattus norvegicus)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Rattus norvegicus)
PRPP [cytosol]
Metabolism of nucleotides (Rattus norvegicus)
Nucleotide biosynthesis (Rattus norvegicus)
Purine ribonucleoside monophosphate biosynthesis (Rattus norvegicus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)
PRPP [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Rattus norvegicus)
PRPP [cytosol]
Pyrimidine biosynthesis (Rattus norvegicus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)
PRPP [cytosol]
Nucleotide salvage (Rattus norvegicus)
Purine salvage (Rattus norvegicus)
APRT catalyzes the conversion of adenine to AMP (Rattus norvegicus)
PRPP [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Rattus norvegicus)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Nicotinate metabolism (Rattus norvegicus)
Nicotinamide salvaging (Rattus norvegicus)
NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)
PRPP [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)
PRPP [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)
PRPP [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of carbohydrates (Saccharomyces cerevisiae)
Pentose phosphate pathway (Saccharomyces cerevisiae)
5-Phosphoribose 1-diphosphate biosynthesis (Saccharomyces cerevisiae)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Saccharomyces cerevisiae)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Saccharomyces cerevisiae)
PRPP [cytosol]
Metabolism of nucleotides (Saccharomyces cerevisiae)
Nucleotide salvage (Saccharomyces cerevisiae)
Purine salvage (Saccharomyces cerevisiae)
APRT catalyzes the conversion of adenine to AMP (Saccharomyces cerevisiae)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Nicotinate metabolism (Saccharomyces cerevisiae)
QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)
PRPP [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of carbohydrates (Schizosaccharomyces pombe)
Pentose phosphate pathway (Schizosaccharomyces pombe)
5-Phosphoribose 1-diphosphate biosynthesis (Schizosaccharomyces pombe)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Schizosaccharomyces pombe)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Schizosaccharomyces pombe)
PRPP [cytosol]
Metabolism of nucleotides (Schizosaccharomyces pombe)
Nucleotide salvage (Schizosaccharomyces pombe)
Purine salvage (Schizosaccharomyces pombe)
APRT catalyzes the conversion of adenine to AMP (Schizosaccharomyces pombe)
PRPP [cytosol]
Drug ADME (Sus scrofa)
Azathioprine ADME (Sus scrofa)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Sus scrofa)
PRPP [cytosol]
Metabolism (Sus scrofa)
Metabolism of carbohydrates (Sus scrofa)
Pentose phosphate pathway (Sus scrofa)
5-Phosphoribose 1-diphosphate biosynthesis (Sus scrofa)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Sus scrofa)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Sus scrofa)
PRPP [cytosol]
Metabolism of nucleotides (Sus scrofa)
Nucleotide biosynthesis (Sus scrofa)
Purine ribonucleoside monophosphate biosynthesis (Sus scrofa)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)
PRPP [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Sus scrofa)
PRPP [cytosol]
Pyrimidine biosynthesis (Sus scrofa)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)
PRPP [cytosol]
Nucleotide salvage (Sus scrofa)
Purine salvage (Sus scrofa)
APRT catalyzes the conversion of adenine to AMP (Sus scrofa)
PRPP [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Sus scrofa)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Nicotinate metabolism (Sus scrofa)
Nicotinamide salvaging (Sus scrofa)
NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)
PRPP [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)
PRPP [cytosol]
Drug ADME (Xenopus tropicalis)
Azathioprine ADME (Xenopus tropicalis)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Xenopus tropicalis)
PRPP [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of carbohydrates (Xenopus tropicalis)
Pentose phosphate pathway (Xenopus tropicalis)
5-Phosphoribose 1-diphosphate biosynthesis (Xenopus tropicalis)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Xenopus tropicalis)
PRPP [cytosol]
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Xenopus tropicalis)
PRPP [cytosol]
Metabolism of nucleotides (Xenopus tropicalis)
Nucleotide biosynthesis (Xenopus tropicalis)
Purine ribonucleoside monophosphate biosynthesis (Xenopus tropicalis)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)
PRPP [cytosol]
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer (Xenopus tropicalis)
PRPP [cytosol]
Pyrimidine biosynthesis (Xenopus tropicalis)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Xenopus tropicalis)
PRPP [cytosol]
Nucleotide salvage (Xenopus tropicalis)
Purine salvage (Xenopus tropicalis)
APRT catalyzes the conversion of adenine to AMP (Xenopus tropicalis)
PRPP [cytosol]
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Xenopus tropicalis)
PRPP [cytosol]
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Nicotinate metabolism (Xenopus tropicalis)
Nicotinamide salvaging (Xenopus tropicalis)
NAMPT transfers PRIB to NAM to form NAMN (Xenopus tropicalis)
PRPP [cytosol]
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Xenopus tropicalis)
PRPP [cytosol]
QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)
PRPP [cytosol]
External Reference Information
External Reference
5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-) [ChEBI:58017]
Participates
as an input of
orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate (Gallus gallus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate + pyrophosphate (Gallus gallus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Plasmodium falciparum)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Dictyostelium discoideum)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Caenorhabditis elegans)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Gallus gallus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Xenopus tropicalis)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Danio rerio)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Sus scrofa)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Bos taurus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Canis familiaris)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Rattus norvegicus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Mus musculus)
HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP (Homo sapiens)
Defective APRT does not convert adenine to AMP (Homo sapiens)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Dictyostelium discoideum)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Caenorhabditis elegans)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Drosophila melanogaster)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Gallus gallus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Xenopus tropicalis)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Danio rerio)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Sus scrofa)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Bos taurus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Canis familiaris)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Rattus norvegicus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Mus musculus)
UMPS dimer transfers phosphoribosyl group to ORO to form OMP (Homo sapiens)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Plasmodium falciparum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Dictyostelium discoideum)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Caenorhabditis elegans)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Drosophila melanogaster)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Gallus gallus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Xenopus tropicalis)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Danio rerio)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Bos taurus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Canis familiaris)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Rattus norvegicus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Mus musculus)
NAPRT1 dimer transfers PRIB to NCA to form NAMN (Homo sapiens)
QPRT transfers PRIB to QUIN to form NAMN (Saccharomyces cerevisiae)
QPRT transfers PRIB to QUIN to form NAMN (Dictyostelium discoideum)
QPRT transfers PRIB to QUIN to form NAMN (Gallus gallus)
QPRT transfers PRIB to QUIN to form NAMN (Xenopus tropicalis)
QPRT transfers PRIB to QUIN to form NAMN (Sus scrofa)
QPRT transfers PRIB to QUIN to form NAMN (Bos taurus)
QPRT transfers PRIB to QUIN to form NAMN (Canis familiaris)
QPRT transfers PRIB to QUIN to form NAMN (Rattus norvegicus)
QPRT transfers PRIB to QUIN to form NAMN (Mus musculus)
QPRT transfers PRIB to QUIN to form NAMN (Homo sapiens)
NAMPT transfers PRIB to NAM to form NAMN (Gallus gallus)
NAMPT transfers PRIB to NAM to form NAMN (Xenopus tropicalis)
NAMPT transfers PRIB to NAM to form NAMN (Danio rerio)
NAMPT transfers PRIB to NAM to form NAMN (Sus scrofa)
NAMPT transfers PRIB to NAM to form NAMN (Bos taurus)
NAMPT transfers PRIB to NAM to form NAMN (Canis familiaris)
NAMPT transfers PRIB to NAM to form NAMN (Rattus norvegicus)
NAMPT transfers PRIB to NAM to form NAMN (Mus musculus)
NAMPT transfers PRIB to NAM to form NAMN (Homo sapiens)
APRT catalyzes the conversion of adenine to AMP (Saccharomyces cerevisiae)
APRT catalyzes the conversion of adenine to AMP (Schizosaccharomyces pombe)
APRT catalyzes the conversion of adenine to AMP (Caenorhabditis elegans)
APRT catalyzes the conversion of adenine to AMP (Drosophila melanogaster)
APRT catalyzes the conversion of adenine to AMP (Gallus gallus)
APRT catalyzes the conversion of adenine to AMP (Xenopus tropicalis)
APRT catalyzes the conversion of adenine to AMP (Danio rerio)
APRT catalyzes the conversion of adenine to AMP (Sus scrofa)
APRT catalyzes the conversion of adenine to AMP (Bos taurus)
APRT catalyzes the conversion of adenine to AMP (Canis familiaris)
APRT catalyzes the conversion of adenine to AMP (Rattus norvegicus)
APRT catalyzes the conversion of adenine to AMP (Mus musculus)
APRT catalyzes the conversion of adenine to AMP (Homo sapiens)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Plasmodium falciparum)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Dictyostelium discoideum)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Caenorhabditis elegans)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Gallus gallus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Xenopus tropicalis)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Danio rerio)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Sus scrofa)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Homo sapiens)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Mus musculus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Rattus norvegicus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Bos taurus)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Danio rerio)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Xenopus tropicalis)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Drosophila melanogaster)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Caenorhabditis elegans)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Canis familiaris)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Sus scrofa)
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate (Gallus gallus)
Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP (Homo sapiens)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Homo sapiens)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Mus musculus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Rattus norvegicus)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Canis familiaris)
HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP (Bos taurus)
as an output of
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Mus musculus)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Homo sapiens)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Rattus norvegicus)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Canis familiaris)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Bos taurus)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Sus scrofa)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Danio rerio)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Xenopus tropicalis)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Gallus gallus)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Dictyostelium discoideum)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Schizosaccharomyces pombe)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Saccharomyces cerevisiae)
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate (Plasmodium falciparum)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Mus musculus)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Homo sapiens)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Rattus norvegicus)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Canis familiaris)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Bos taurus)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Sus scrofa)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Danio rerio)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Xenopus tropicalis)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Gallus gallus)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Dictyostelium discoideum)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Schizosaccharomyces pombe)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Saccharomyces cerevisiae)
D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate (Plasmodium falciparum)
This entity regulates
Negatively
Formation of PPAT tetramers
(Gallus gallus)
Positively
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Gallus gallus)
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Rattus norvegicus)
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Mus musculus)
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Homo sapiens)
Formation of PPAT dimers
(Gallus gallus)
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Caenorhabditis elegans)
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Drosophila melanogaster)
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Xenopus tropicalis)
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Danio rerio)
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Sus scrofa)
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Bos taurus)
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
(Canis familiaris)
Cross References
COMPOUND
C00119
ZINC
000008215630
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