pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate

Stable Identifier
R-GGA-353154
Type
Reaction [transition]
Species
Gallus gallus
Compartment
mitochondrial matrix
Synonyms
Carboxylation of pyruvate to form oxaloacetate
ReviewStatus
5/5
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pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate
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Pyruvate carboxylase catalyzes the reaction of pyruvate, ATP, and bicarbonate to form oxaloacetate, ADP, and orthophosphate. The active form of the enzyme is a tetramer, with one molecule each of biotin and Mn++ associated with each protein monomer. The reaction requires Mg++. Acetyl CoA is an allosteric activator of pyruvate carboxylase; the reaction does not proceed to a significant extent in its absence (Keech and Utter 1963; Scrutton and Utter 1967; Jitrapakdee et al. 2002).
Literature References
PubMed ID Title Journal Year
12150961 Molecular cloning and domain structure of chicken pyruvate carboxylase

Jitrapakdee, S, Nezic, MG, Cassady, AI, Khew-Goodall, Y, Wallace, JC

Biochem Biophys Res Commun 2002
6024765 Pyruvate carboxylase. IX. Some properties of the activation by certain acyl derivatives of coenzyme A

Scrutton, MC, Utter, MF

J Biol Chem 1967
14063280 Pyruvate carboxylase. II. Properties

Keech, DB, Utter, MF

J Biol Chem 1963
Participants
Input
Output
Participates
as an event of
Catalyst Activity

pyruvate carboxylase activity of PYC [mitochondrial matrix]

Physical Entity
PYC [mitochondrial matrix] (Gallus gallus)
Activity
pyruvate carboxylase activity (GO:0004736)
This event is regulated
Requirements
Authored
D'Eustachio, P  (2008-09-10)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2008-06-11)
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