Reactome | magoh [nucleoplasm]

magoh [nucleoplasm]

Stable Identifier

R-DRE-156658

Type

Protein [EntityWithAccessionedSequence]

Species

Danio rerio

Compartment

nucleoplasm

Synonyms

MAGOH, Q566Y8

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
- Processing of Capped Intron-Containing Pre-mRNA (Danio rerio)
  - Transport of Mature Transcript to Cytoplasm (Danio rerio)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Danio rerio)
      - NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B) (Danio rerio)
        
        NXF1,2:NXT1::polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Danio rerio)
        
        capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm] (Danio rerio)
        
        EJC [nucleoplasm] (Danio rerio)
        
        Core EJC [nucleoplasm] (Danio rerio)
        
        Magoh-Y14 complex [nucleoplasm] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
        
        polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm] (Danio rerio)
        
        EJC [nucleoplasm] (Danio rerio)
        
        Core EJC [nucleoplasm] (Danio rerio)
        
        Magoh-Y14 complex [nucleoplasm] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
      - Transport of the export-competent mRNP complex through the NPC (Danio rerio)
        
        NPC:NXF1,2:NXT1:EJC:CBC:mRNA [nucleoplasm] (Danio rerio)
        
        EJC [nucleoplasm] (Danio rerio)
        
        Core EJC [nucleoplasm] (Danio rerio)
        
        Magoh-Y14 complex [nucleoplasm] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Danio rerio)
        
        EJC [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
      - mRNP complex dissociates from cytosolic face of NPC (Danio rerio)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Danio rerio)
        
        EJC [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Danio rerio)
        
        EJC [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
  - mRNA Splicing (Danio rerio)
    - mRNA Splicing - Major Pathway (Danio rerio)
      - Formation of the Spliceosomal C complex containing intron lariat (Danio rerio)
        
        Spliceosomal B* complex [nucleoplasm] (Danio rerio)
        
        Core EJC [nucleoplasm] (Danio rerio)
        
        Magoh-Y14 complex [nucleoplasm] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
        
        Spliceosomal C complex [nucleoplasm] (Danio rerio)
        
        Core EJC [nucleoplasm] (Danio rerio)
        
        Magoh-Y14 complex [nucleoplasm] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
      - Formation of the Spliceosomal P complex and exon ligation (Danio rerio)
        
        Spliceosomal C* complex [nucleoplasm] (Danio rerio)
        
        Core EJC [nucleoplasm] (Danio rerio)
        
        Magoh-Y14 complex [nucleoplasm] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)
        
        Spliceosomal P complex [nucleoplasm] (Danio rerio)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Danio rerio)
        
        EJC [nucleoplasm] (Danio rerio)
        
        Core EJC [nucleoplasm] (Danio rerio)
        
        Magoh-Y14 complex [nucleoplasm] (Danio rerio)
        
        magoh [nucleoplasm] (Danio rerio)

External Reference Information

External Reference

UniProt:Q566Y8

Gene Names

magoh

Reference Genes

BioGPS Gene:100005893 magoh

ENSEMBL:ENSDARG00000038635

KEGG:dre:100005893 magoh

Monarch:100005893 magoh

NCBI Gene:100005893 magoh

UCSC:Q566Y8 magoh

Reference Transcript

RefSeq:NM_001017700.1 magoh

Other Identifiers

100005893

13244968

A_15_P189256

CUST_2875_PI428451958

DRER07301

Dr.13517.1.S1_at

ENSDART00000056405

ENSDART00000056405_1

ENSDART00000056405_2

GO:0005634

GO:0008380

GO:0035145

GT_Spec_NM_001017700.1_139726

LOLS08291

MADDr01010360

NM_001017700

OTTDART00000028720

Participates

as a component of

Other forms of this molecule

magoh [nucleoplasm]

Inferred From

MAGOH,MAGOHB [nucleoplasm] (Homo sapiens)

MAGOH [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001017700.1

ENSEMBL

ENSDART00000181585, ENSDARG00000038635, ENSDART00000056405, ENSDARG00000109837, ENSDARP00000056404, ENSDARP00000146033

ZFIN

ZDB-GENE-041216-1

PRO

Q566Y8

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