Reactome | Magoh-Y14 complex [cytosol]

Magoh-Y14 complex [cytosol]

Stable Identifier

R-DRE-162463

Type

Complex

Species

Danio rerio

Compartment

cytosol

Locations in the PathwayBrowser

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Metabolism of RNA (Danio rerio)

- Nonsense-Mediated Decay (NMD) (Danio rerio)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Danio rerio)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
    - SMG6 hydrolyzes mRNA with premature termination codon (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Danio rerio)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Danio rerio)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Danio rerio)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Danio rerio)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
- Processing of Capped Intron-Containing Pre-mRNA (Danio rerio)
  - Transport of Mature Transcript to Cytoplasm (Danio rerio)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Danio rerio)
      - Transport of the export-competent mRNP complex through the NPC (Danio rerio)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Danio rerio)
        
        EJC [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
      - mRNP complex dissociates from cytosolic face of NPC (Danio rerio)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Danio rerio)
        
        EJC [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Danio rerio)
        
        EJC [cytosol] (Danio rerio)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)
        
        Magoh-Y14 complex [cytosol] (Danio rerio)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a component of

Core Exon Junction Complex (Core EJC) [cytosol] (Danio rerio)

Inferred From

Magoh-Y14 complex [cytosol] (Homo sapiens)