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Diap1 [cytosol]
Stable Identifier
R-DME-50849
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
XIAP, Q24306
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Drosophila melanogaster)
Apoptosis (Drosophila melanogaster)
Intrinsic Pathway for Apoptosis (Drosophila melanogaster)
Apoptotic factor-mediated response (Drosophila melanogaster)
Cytochrome c-mediated apoptotic response (Drosophila melanogaster)
Activation of caspases through apoptosome-mediated cleavage (Drosophila melanogaster)
Cleavage of Procaspase-3 by the apoptosome (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
Cleavage of Procaspase-7 by the apoptosome (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
Formation of apoptosome (Drosophila melanogaster)
Regulation of the apoptosome activity (Drosophila melanogaster)
XIAP binds CASP9 (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
XIAP:apoptosome [cytosol] (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
SMAC, XIAP-regulated apoptotic response (Drosophila melanogaster)
SEPT4 binds XIAP (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
SEPT4 dimer:XIAP [cytosol] (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
XIAP binds CASP3 (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
XIAP:Caspase-3 [cytosol] (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
XIAP binds CASP7 (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
XIAP:Caspase-7 [cytosol] (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
Regulated Necrosis (Drosophila melanogaster)
RIPK1-mediated regulated necrosis (Drosophila melanogaster)
Regulation of necroptotic cell death (Drosophila melanogaster)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Drosophila melanogaster)
BIRC2,3,4 [cytosol] (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
PTEN Regulation (Drosophila melanogaster)
Regulation of PTEN localization (Drosophila melanogaster)
PTEN undergoes monoubiquitination (Drosophila melanogaster)
XIAP,NEDD4 [cytosol] (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
Regulation of PTEN stability and activity (Drosophila melanogaster)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Drosophila melanogaster)
NEDD4,STUB1,WWP2 and XIAP [cytosol] (Drosophila melanogaster)
Diap1 [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q24306 Diap1
Gene Names
Diap1, Iap1, th, CG12284
Chain
chain:1-438
Reference Genes
BioGPS Gene:39753 Diap1
CTD Gene:39753 Diap1
KEGG Gene (Drosophila melanogaster):Dmel_CG12284 Diap1
Monarch:39753 Diap1
NCBI Gene:39753 Diap1
Reference Transcript
RefSeq:NM_079377.3 Diap1
RefSeq:NM_001274987.1 Diap1
RefSeq:NM_001274989.1 Diap1
RefSeq:NM_168645.2 Diap1
RefSeq:NM_168644.2 Diap1
RefSeq:NM_001274988.1 Diap1
Other Identifiers
152631_at
1636787_s_at
39753
GO:0000003
GO:0000209
GO:0000278
GO:0003674
GO:0004842
GO:0004869
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005876
GO:0006464
GO:0006511
GO:0006915
GO:0007010
GO:0007049
GO:0007165
GO:0007267
GO:0007275
GO:0007283
GO:0007289
GO:0007298
GO:0008150
GO:0008219
GO:0008270
GO:0008354
GO:0009056
GO:0010804
GO:0016055
GO:0016740
GO:0019899
GO:0022416
GO:0022607
GO:0030154
GO:0030234
GO:0031398
GO:0031624
GO:0031625
GO:0040011
GO:0043027
GO:0043066
GO:0043154
GO:0043167
GO:0043226
GO:0044390
GO:0045035
GO:0045116
GO:0046673
GO:0046872
GO:0048471
GO:0048800
GO:0048856
GO:0048870
GO:0051301
GO:0051604
GO:0051865
GO:0061630
GO:0061663
GO:0070936
GO:0089720
GO:0090263
GO:0090307
GO:0097340
GO:0140014
GO:1903688
GO:1990001
GO:1990381
GO:2001271
Participant Of
hasCandidate
BIRC2,3,4 [cytosol]
XIAP,NEDD4 [cytosol]
input
SEPT4 binds XIAP
XIAP binds CASP3
XIAP binds CASP7
XIAP binds CASP9
hasComponent
SEPT4 dimer:XIAP [cytosol]
XIAP:apoptosome [cytosol]
XIAP:Caspase-3 [cytosol]
XIAP:Caspase-7 [cytosol]
hasMember
NEDD4,STUB1,WWP2 and XIAP [cytosol]
This entity regulates
Negatively
Cleavage of Procaspase-3 by the apoptosome
Other forms of this molecule
Phospho TH [cytosol]
TH [cytosol]
Diap1 [cytosol]
Diap1 [nucleoplasm]
Inferred From
XIAP [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_730098.1
,
NP_524101.2
,
NP_001261917.1
,
NP_730097.1
,
NP_001261918.1
,
NP_001261916.1
Flybase
FBgn0260635
PRO
Q24306
PDB
1SE0
,
1Q4Q
,
1JD6
,
1SDZ
,
3SIP
,
1JD5
,
3SIQ
,
1JD4
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9XYF4
24
Dronc [cytosol]
(R-DME-3465404)
Dronc [cytosol]
(R-DME-3465483)
Dronc [cytosol]
(R-DME-3465408)
Dronc [cytosol]
(R-DME-3371356)
Dronc [mitochondrial outer membrane]
(R-DME-351869)
Dronc [mitochondrial outer membrane]
(R-DME-351828)
Dronc [cytosol]
(R-DME-933453)
Dronc [cytosol]
(R-DME-2976746)
Dronc [cytosol]
(R-DME-2976745)
Dronc [cytosol]
(R-DME-622412)
Dronc [cytosol]
(R-DME-448680)
Dronc [cytosol]
(R-DME-448674)
Dronc [cytosol]
(R-DME-448692)
Dronc [cytosol]
(R-DME-448686)
Dronc [cytosol]
(R-DME-448704)
phospho-Dronc [cytosol]
(R-DME-9627087)
Dronc [cytosol]
(R-DME-141639)
Dronc [cytosol]
(R-DME-141638)
Dronc [cytosol]
(R-DME-3465357)
Dronc [cytosol]
(R-DME-57031)
Dronc [cytosol]
(R-DME-76158)
Dronc [cytosol]
(R-DME-75975)
phospho-Dronc [cytosol]
(R-DME-198636)
Dronc [cytosol]
(R-DME-57033)
0.908
11
UniProt:Q24106 HID
0.87
9
UniProt:Q24475 RPR
0.822
7
UniProt:Q86PE7 Q86PE7
0.602
3
UniProt:O02002
4
Dcp-1 [nucleoplasm]
(R-DME-352247-2)
Dcp-1 [nucleoplasm]
(R-DME-352246-2)
Dcp-1 [cytosol]
(R-DME-350313-2)
Dcp-1 [cytosol]
(R-DME-266128-2)
0.534
2
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