OGDH dimer decarboxylates 2-OG

Stable Identifier
R-DDI-71401
Type
Reaction [transition]
Species
Dictyostelium discoideum
Compartment
mitochondrial matrix
Synonyms
2-oxoglutarate + H(+) + N(6)-((R)-lipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase) => CO2 + N(6)-((R)-S(8)-succinyldihydrolipoyl)-L-lysyl-(dihydrolipoyllysine-residue succinyltransferase), Oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA by alpha-ketoglutarate dehydrogenase
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OGDH dimer decarboxylates 2-OG
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Participants
Input
Output
Participates
as an event of
Catalyst Activity

oxoglutarate dehydrogenase (succinyl-transferring) activity of OGDH complex [mitochondrial matrix]

Physical Entity
OGDH complex [mitochondrial matrix] (Dictyostelium discoideum)
Activity
oxoglutarate dehydrogenase (succinyl-transferring) activity (GO:0004591)
This event is regulated
Negatively by
Regulator
Ca2+ [mitochondrial matrix]
Regulator
ADP [mitochondrial matrix]
Positively by
Regulator
NADH [mitochondrial matrix]
Regulator
ATP [mitochondrial matrix]
Inferred From
OGDH dimer decarboxylates 2-OG (Homo sapiens)
Created
Weiser, JD  (2024-05-25)
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