Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SHC1 [cytosol]
Stable Identifier
R-CFA-74680
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
SHC1, A0A8I3NUU1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
RET signaling (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 in the RET complex is phosphorylated (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Cell surface interactions at the vascular wall (Canis familiaris)
Tie2 Signaling (Canis familiaris)
Interaction of Tie2 and Shc1 (Canis familiaris)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Platelet Aggregation (Plug Formation) (Canis familiaris)
Integrin signaling (Canis familiaris)
Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-2 family signaling (Canis familiaris)
Interleukin-2 signaling (Canis familiaris)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 bound to IL2 receptor is phosphorylated (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Integrin signaling (Canis familiaris)
Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Canis familiaris)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Signaling by Nuclear Receptors (Canis familiaris)
ESR-mediated signaling (Canis familiaris)
Extra-nuclear estrogen signaling (Canis familiaris)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Canis familiaris)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
MMPs cleave HB-EGF (Canis familiaris)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by EGFR (Canis familiaris)
SHC1 events in EGFR signaling (Canis familiaris)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
SHC1 events in ERBB2 signaling (Canis familiaris)
SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Signaling by ERBB4 (Canis familiaris)
SHC1 events in ERBB4 signaling (Canis familiaris)
Phosphorylation of SHC1 by ERBB4 homodimers (Canis familiaris)
SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 binds P-ERBB4 isoform dimers (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
Binding of SHC1 to insulin receptor (Canis familiaris)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
Phosphorylation of SHC1 (Canis familiaris)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Canis familiaris)
SHC1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NUU1
Gene Names
SHC1
Reference Genes
ENSEMBL:ENSCAFG00845014088.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845014088.1 SHC1
Other Identifiers
490439
Cfa.14843.1.A1_at
Cfa.18402.1.S1_s_at
Cfa.4908.1.A1_s_at
Cfa.5719.1.A1_at
CfaAffx.26236.1.S1_s_at
GO:0001525
GO:0001784
GO:0005068
GO:0005158
GO:0005159
GO:0005168
GO:0005886
GO:0006351
GO:0006355
GO:0007010
GO:0007155
GO:0007173
GO:0007507
GO:0012501
GO:0023052
GO:0030036
GO:0030971
GO:0035556
GO:0042127
GO:0042742
GO:0043066
GO:0043410
GO:0045892
GO:0045893
GO:0046875
GO:0048009
GO:0048408
GO:0048856
GO:0060090
GO:0070374
GO:0071363
GO:0098542
GO:0098609
Participates
as an input of
Activated integrin alphaIIb beta3 binds SHC1 (Canis familiaris)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Canis familiaris)
Interaction of Tie2 and Shc1 (Canis familiaris)
Binding of SHC1 to insulin receptor (Canis familiaris)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Canis familiaris)
SHC1 binds P-ERBB4 isoform dimers (Canis familiaris)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Canis familiaris)
as a component of
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Canis familiaris)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Canis familiaris)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Canis familiaris)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Canis familiaris)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Canis familiaris)
IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Canis familiaris)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Canis familiaris)
SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Canis familiaris)
Other forms of this molecule
SHC1 [plasma membrane]
SHC1 [plasma membrane]
SHC1 [plasma membrane]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
SHC1 [cytosol]
SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
phospho-SHC1 [plasma membrane]
phospho-SHC1 [plasma membrane]
phospho-SHC1 [cytosol]
phospho-SHC1 [cytosol]
Inferred From
SHC1 [cytosol]
(Homo sapiens)
SHC1-1 [cytosol]
(Homo sapiens)
SHC1 [cytosol]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000160691
Ensembl
ENSCAFG00845014088
,
ENSCAFT00845025220
,
ENSCAFP00845019833
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text