Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SHC1-1 [cytosol]
Stable Identifier
R-HSA-1433366
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHC1 p66, SHC1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
GPER1 signaling (Homo sapiens)
SHC1 is phosphorylated downstream of estrogen stimulation of GPER1 (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
SHC1-1 [cytosol] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Homo sapiens)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
SHC1-1 [cytosol] (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
SHC1-1 [cytosol] (Homo sapiens)
MMPs cleave HB-EGF (Homo sapiens)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Homo sapiens)
SHC1 [cytosol] (Homo sapiens)
SHC1-1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29353-1 SHC1
Gene Names
SHC1, SHC, SHCA
Other Identifiers
0003840148
0004480253
0006370025
11727363_a_at
11727364_s_at
11732136_a_at
11758297_s_at
16693891
16693898
201469_PM_s_at
201469_s_at
214853_PM_s_at
214853_s_at
2436980
2436981
2436982
2436983
2436984
2436986
2436987
2436988
2436989
2436990
2436991
2436992
2436995
2436996
2436997
2436998
2436999
2437000
2437002
2437003
2437004
2437005
2437006
2437007
2437009
2437010
2437011
2437012
2437013
2437014
2437015
2437016
2437018
3759015
3759016
38118_at
6464
7920600
A_23_P200443
A_24_P68585
GE59385
GO:0001525
GO:0001784
GO:0002376
GO:0003674
GO:0005068
GO:0005154
GO:0005158
GO:0005159
GO:0005168
GO:0005515
GO:0005543
GO:0005575
GO:0005622
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0005886
GO:0006464
GO:0006950
GO:0007010
GO:0007155
GO:0007165
GO:0007169
GO:0007173
GO:0007176
GO:0007507
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008286
GO:0008289
GO:0009058
GO:0016525
GO:0019899
GO:0019901
GO:0030674
GO:0030971
GO:0031532
GO:0032991
GO:0034641
GO:0035556
GO:0040007
GO:0040008
GO:0042127
GO:0042742
GO:0043066
GO:0043226
GO:0043410
GO:0045892
GO:0045893
GO:0046875
GO:0048408
GO:0048646
GO:0048856
GO:0070374
GO:0070435
GO:0071363
GO:0071864
GO:0090322
GO:0098609
HMNXSV003029143
HMNXSV003056955
Hs.81972.0.A1_3p_a_at
Hs.81972.1.A1_3p_a_at
ILMN_1701967
ILMN_1721022
ILMN_1812570
PH_hs_0030190
TC01006381.hg
U73377_at
Participates
as a member of
SHC1 [cytosol] (Homo sapiens)
Other forms of this molecule
SHC1 [plasma membrane]
p-S139,3Y-SHC1-1 [cytosol]
p-Y349,Y350,Y427-SHC1-1 [cytosol]
Inferred To
Shc [cytosol]
(Drosophila melanogaster)
Shc1 [cytosol]
(Mus musculus)
Shc1 [cytosol]
(Rattus norvegicus)
shc1 [cytosol]
(Danio rerio)
SHC1 [cytosol]
(Bos taurus)
SHC1 [cytosol]
(Canis familiaris)
SHC1 [cytosol]
(Gallus gallus)
SHC1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001189788.1
,
NP_003020.2
,
NP_001123513.1
,
NP_892113.4
,
NP_001123512.1
OpenTargets
ENSG00000160691
HPA
ENSG00000160691-SHC1
GeneCards
P29353
ZINC - Substances
SHC1_HUMAN
ZINC target
P29353
Ensembl
ENSP00000357430
,
ENSP00000357438
,
ENST00000448116
,
ENST00000368450
,
ENST00000368453
,
ENSP00000357435
,
ENSP00000401303
,
ENSG00000160691
,
ENST00000368445
PRO
P29353
Pharos - Targets
P29353
ZINC - Predictions - Purchasable
SHC1_HUMAN
PDB
6DM4
,
1SHC
,
1MIL
,
5CZI
,
4JMH
,
1N3H
,
2L1C
,
1OY2
,
1QG1
,
4XWX
,
1TCE
Interactors (37)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.974
31
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.973
41
UniProt:P62994 Grb2
3
Grb2 [cytosol]
(R-RNO-55929)
Grb2 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-74686)
0.822
5
UniProt:P27986 PIK3R1
15
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.816
6
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.813
8
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665656)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.772
15
UniProt:P22681 CBL
20
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL del366-409 [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
CBL G375fs*16 [cytosol]
(R-HSA-9706211)
0.77
5
UniProt:P21860 ERBB3
0.702
6
UniProt:O95782 AP2A1
5
AP2A1 [endolysosome membrane]
(R-HSA-6784829)
AP2A1 [endocytic vesicle membrane]
(R-HSA-416641)
AP2A1 [plasma membrane]
(R-HSA-177494)
AP2A1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138449)
AP2A1 [cytosol]
(R-HSA-182143)
0.643
5
UniProt:O94973 AP2A2
6
AP2A2(1-939) [endolysosome membrane]
(R-HSA-6784819)
AP2A2(1-939) [ficolin-1-rich granule membrane]
(R-HSA-6800414)
AP2A2(1-939) [secretory granule membrane]
(R-HSA-6800412)
AP2A2(1-939) [plasma membrane]
(R-HSA-177502)
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138448)
AP2A2(1-939) [cytosol]
(R-HSA-182155)
0.643
4
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.643
5
UniProt:Q15303 ERBB4
0.609
6
UniProt:Q12774 ARHGEF5
1
ARHGEF5 [cytosol]
(R-HSA-8873909)
0.597
4
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.589
6
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.573
2
UniProt:P29353 SHC1
5
SHC1 [cytosol]
(R-HSA-74680)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
0.564
2
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.564
2
UniProt:P35968 KDR
4
p-11Y VEGFR2(20-674)-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-674)-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.564
2
UniProt:Q13137 CACO2
0.553
3
UniProt:P33151 CDH5
2
p-S665-VE-cadherin [plasma membrane]
(R-HSA-5357435)
VE-cadherin [plasma membrane]
(R-HSA-418992)
0.544
2
UniProt:P26954 IL3B2
0.544
4
UniProt:P16573
11
Ceacam1 [extracellular region]
(R-RNO-8941137-3)
Ceacam1 [plasma membrane]
(R-RNO-8940816-3)
Ceacam1 [extracellular region]
(R-RNO-8870747-3)
Ceacam1 [extracellular region]
(R-RNO-8870766-3)
Ceacam1 [extracellular region]
(R-RNO-8870757-3)
Ceacam1 [extracellular region]
(R-RNO-8870759-3)
Ceacam1 [tertiary granule membrane]
(R-RNO-6800953)
Ceacam1 [plasma membrane]
(R-RNO-197706-3)
Ceacam1 [plasma membrane]
(R-RNO-197701)
Ceacam1 [specific granule membrane]
(R-RNO-6806076-3)
Ceacam1 [specific granule membrane]
(R-RNO-6799528)
0.544
3
UniProt:Q9UQC2 GAB2
5
p-Y-GAB2 [cytosol]
(R-HSA-912529)
GAB2 [cytosol]
(R-HSA-508239)
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
p-Y643-GAB2 [cytosol]
(R-HSA-9677149)
0.544
2
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [plasma membrane]
(R-HSA-167690)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
0.527
3
UniProt:Q8TF42 UBS3B
0.527
3
UniProt:Q38SD2 LRRK1
0.527
3
UniProt:P32927 CSF2RB
6
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
CSF2RB [plasma membrane]
(R-HSA-879960)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
0.527
4
UniProt:Q93008 USP9X
1
USP9X [cytosol]
(R-HSA-870499)
0.527
3
UniProt:Q05655 PRKCD
12
PRKCD(1-676) [nucleoplasm]
(R-HSA-450606)
PRKCD(330-676) [extracellular region]
(R-HSA-6806199)
PRKCD(1-329) [extracellular region]
(R-HSA-6806226)
PRKCD(1-329) [azurophil granule lumen]
(R-HSA-6799219)
PRKCD(330-676) [azurophil granule lumen]
(R-HSA-6799221)
p-T507-PRKCD [cytosol]
(R-HSA-5218746)
p-T507,S645,S664-PRKCD [cytosol]
(R-HSA-5218734)
active p-T507,S645,S664-PRKCD [plasma membrane]
(R-HSA-5607635)
p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
(R-HSA-198294)
PRKCD(330-676) [cytosol]
(R-HSA-212551)
PRKCD(1-329) [cytosol]
(R-HSA-212547)
PRKCD [cytosol]
(R-HSA-58200)
0.527
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.527
2
UniProt:P03495 NS1
0.508
2
UniProt:Q16832 DDR2
1
DDR2 [plasma membrane]
(R-HSA-211419)
0.508
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.483
3
UniProt:Q08345-1 DDR1
0.462
4
UniProt:A9UF07 A9UF07
0.462
4
UniProt:Q02763 TEK
2
TEK [plasma membrane]
(R-HSA-197755)
p-5Y,S1119-TEK [plasma membrane]
(R-HSA-204772)
0.462
2
UniProt:P04629 NTRK1
4
p-5Y-NTRK1 [Golgi membrane]
(R-HSA-3008810)
NTRK1 [Golgi membrane]
(R-HSA-3008805)
NTRK1 [plasma membrane]
(R-HSA-3008784)
p-5Y-NTRK1 [plasma membrane]
(R-HSA-3009413)
0.462
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text