Reactome | LUBAC [cytosol]

LUBAC [cytosol]

Stable Identifier

R-CFA-5357865

Type

Complex

Species

Canis familiaris

Compartment

cytosol

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General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

RBCK1 [cytosol] (Canis familiaris)
RNF31 [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)

Participates

as an input of

LUBAC binds OTULIN (Canis familiaris)
LUBAC binds CFLAR (Canis familiaris)
SPATA2 links CYLD to LUBAC (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Canis familiaris)

as a component of

LUBAC:OTULIN [cytosol] (Canis familiaris)
CFLAR:LUBAC:Ub:UBE2D3 [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)

as an output of

LUBAC ubiquitinates CFLAR at K351, K353 (Canis familiaris)

Inferred From

LUBAC [cytosol] (Homo sapiens)

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