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SHARPIN [cytosol]
Stable Identifier
R-CFA-5212666
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
SHARPIN, A0A8I3N2B0
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
LUBAC binds CFLAR (Canis familiaris)
CFLAR:LUBAC:Ub:UBE2D3 [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
LUBAC binds OTULIN (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
LUBAC:OTULIN [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
LUBAC ubiquitinates CFLAR at K351, K353 (Canis familiaris)
CFLAR:LUBAC:Ub:UBE2D3 [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
SPATA2 links CYLD to LUBAC (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
TNFR1-induced proapoptotic signaling (Canis familiaris)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
SHARPIN [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N2B0
Gene Names
SHARPIN
Reference Genes
ENSEMBL:ENSCAFG00845008013.1
UCSC:A0A8I3N2B0 SHARPIN
Other Identifiers
475122
CfaAffx.3196.1.S1_at
CfaAffx.3197.1.S1_s_at
Participates
as a component of
LUBAC [cytosol] (Canis familiaris)
Inferred From
SHARPIN [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFG00845008013
,
ENSCAFP00845010935
,
ENSCAFT00845014110
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