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Ghost homologue of SHARPIN [cytosol]
Stable Identifier
R-CFA-5212666
Type
Genes and Transcripts [GenomeEncodedEntity]
Species
Canis familiaris
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
TNF signaling (Canis familiaris)
Regulation of TNFR1 signaling (Canis familiaris)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Canis familiaris)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
TNFR1-induced proapoptotic signaling (Canis familiaris)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Canis familiaris)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
LUBAC [cytosol] (Canis familiaris)
Ghost homologue of SHARPIN [cytosol] (Canis familiaris)
Participates
as a component of
LUBAC [cytosol] (Canis familiaris)
Inferred From
SHARPIN [cytosol]
(Homo sapiens)
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