Reactome | RNF31 [cytosol]

RNF31 [cytosol]

Stable Identifier

R-CFA-5212660

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

RNF31, A0A8I3MYA4

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Death Receptor Signaling (Canis familiaris)
  - TNF signaling (Canis familiaris)
    - Regulation of TNFR1 signaling (Canis familiaris)
      - CHUK, IKBKB phosphorylate RIPK1 at S25 (Canis familiaris)
        
        TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
      - CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
      - CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
      - CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
      - LUBAC ubiquitinates RIPK1 at K627 (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
      - OPTN binds polyUb-RIPK1 within the TNFR1 complex (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
      - OPTN recruits CYLD to the TNFR1 complex (Canis familiaris)
        
        CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
      - SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
      - TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
      - TBK1, IKBKE phosphorylate RIPK1 at T189 (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
    - TNFR1-induced NF-kappa-B signaling pathway (Canis familiaris)
      - TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
      - TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Canis familiaris)
        
        TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)
    - TNFR1-induced proapoptotic signaling (Canis familiaris)
      - TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Canis familiaris)
        
        TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Canis familiaris)
        
        CYLD:SPATA2:LUBAC [cytosol] (Canis familiaris)
        
        LUBAC [cytosol] (Canis familiaris)
        
        RNF31 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MYA4

Gene Names

RNF31

Reference Genes

ENSEMBL:ENSCAFG00845004714.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845004714.1 RNF31

Other Identifiers

480259

607899

Cfa.18937.1.S1_s_at

Cfa.20239.1.S1_s_at

CfaAffx.18641.1.S1_at

GO:0000209

GO:0002376

GO:0003824

GO:0004842

GO:0005829

GO:0005886

GO:0006914

GO:0008270

GO:0009898

GO:0012501

GO:0016567

GO:0016740

GO:0023035

GO:0023052

GO:0031625

GO:0035631

GO:0036211

GO:0042742

GO:0042802

GO:0043123

GO:0043130

GO:0050852

GO:0060546

GO:0061630

GO:0071797

GO:0097039

GO:0098542

GO:0140096

GO:1904417

Participates

as a component of

LUBAC [cytosol] (Canis familiaris)

Inferred From

RNF31 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000092098

Ensembl

ENSCAFT00845008447, ENSCAFP00845006653, ENSCAFG00845004714

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