Reactome | TRADD [cytosol]

TRADD [cytosol]

Stable Identifier

R-CFA-66376

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

TRADD, A0A8I3NEJ2

Locations in the PathwayBrowser

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Programmed Cell Death (Canis familiaris)

- Apoptosis (Canis familiaris)
  - Caspase activation via extrinsic apoptotic signalling pathway (Canis familiaris)
    - Caspase activation via Death Receptors in the presence of ligand (Canis familiaris)
      - Dimerization of procaspase-8 (Canis familiaris)
        
        TNF-mediated dimerization of procaspase-8 (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
      - Regulation by c-FLIP (Canis familiaris)
        
        Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
        
        FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
- Regulated Necrosis (Canis familiaris)
  - RIPK1-mediated regulated necrosis (Canis familiaris)
    - Regulation of necroptotic cell death (Canis familiaris)
      - CASP8 activity is inhibited (Canis familiaris)
        
        FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
        
        FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
      - RIPK1 is cleaved by CASP8 (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Canis familiaris)
        
        TRADD [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NEJ2

Gene Names

TRADD

Reference Genes

BioGPS Gene:611262 TRADD

ENSEMBL:ENSCAFG00845010243.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845010243.1 TRADD

Monarch:611262 TRADD

NCBI Gene:611262 TRADD

Reference Transcript

RefSeq:XM_014114114.1 TRADD

Other Identifiers

611262

Cfa.19650.1.S1_at

CfaAffx.31209.1.S1_s_at

GO:0002947

GO:0005068

GO:0005515

GO:0005737

GO:0005886

GO:0006954

GO:0007165

GO:0007249

GO:0012501

GO:0019900

GO:0023052

GO:0030335

GO:0033209

GO:0042802

GO:0043123

GO:0043235

GO:0048856

GO:0048870

GO:0050729

GO:0051798

GO:0060090

GO:0070513

GO:0071356

GO:0097191

Participates

as a component of

as an input of

TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)

Inferred From

TRADD [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_013969589.1

OpenTargets

ENSG00000102871

Ensembl

ENSCAFG00845010243, ENSCAFT00845018019, ENSCAFP00845014037

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