Reactome | TRAF2 [cytosol]

TRAF2 [cytosol]

Stable Identifier

R-CFA-66370

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

TRAF2, A0A8I3MQC7

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-1 family signaling (Canis familiaris)
      - Interleukin-1 signaling (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
        
        TRAF2, TRAF6 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
  - TNFR2 non-canonical NF-kB pathway (Canis familiaris)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TRAF1:TRAF2:K63polyUb-cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TRAF1:TRAF2:K63polyUb-cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - Protesomal degradation of K48polyUb-TRAF3 (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TRAF1:TRAF2:K63polyUb-cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - TRAF1:TRAF2:K63polyUb-cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Canis familiaris)
      - TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40 (Canis familiaris)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - TRAF2:cIAP1/2 complex binds FN14:TWEAK (Canis familiaris)
        
        3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - TRAF3 binds BAFFR:BAFF (Canis familiaris)
        
        3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - TRAFs bind RANK:RANKL (Canis familiaris)
        
        3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Canis familiaris)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Canis familiaris)
        
        3xBAFFR:BAFF trimer:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        3xLTBR:lymphotoxin,TNFSF14 trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        3xRANK:RANKL,sRANKL trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        CD40:CD40L trimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TRAF1:TRAF2:K63polyUb-cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - TRAF3:NIK binds TRAF2:cIAP1/2 (Canis familiaris)
      - TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Canis familiaris)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        TRAF1:TRAF2:K63polyUb-cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer (Canis familiaris)
      - TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Canis familiaris)
        
        cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - cIAP1,2:TRAF2:TRAF3:NIK [cytosol] (Canis familiaris)
        
        TRAF2:cIAP1,2 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
        
        TRAF2, TRAF6 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
        
        TRAF2, TRAF6 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
        
        TRAF2, TRAF6 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
        
        TRAF2, TRAF6 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
        
        TRAF2, TRAF6 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
        
        TRAF2, TRAF6 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
        
        TRAF2, TRAF6 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
        
        TRAF2, TRAF6 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        TRAF2,6 ubiquitinates NLRC5 (Canis familiaris)
        
        TRAF2, TRAF6 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)

Programmed Cell Death (Canis familiaris)

- Apoptosis (Canis familiaris)
  - Caspase activation via extrinsic apoptotic signalling pathway (Canis familiaris)
    - Caspase activation via Death Receptors in the presence of ligand (Canis familiaris)
      - Dimerization of procaspase-8 (Canis familiaris)
        
        TNF-mediated dimerization of procaspase-8 (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - Regulation by c-FLIP (Canis familiaris)
        
        Caspase-8 and FLIP(L) processing at DISC (Canis familiaris)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
- Regulated Necrosis (Canis familiaris)
  - RIPK1-mediated regulated necrosis (Canis familiaris)
    - Regulation of necroptotic cell death (Canis familiaris)
      - CASP8 activity is inhibited (Canis familiaris)
        
        FLIP(L) and procaspase-8 form heterodimer (Canis familiaris)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        FLIP(S) and procaspase-8 form heterodimer (Canis familiaris)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
      - RIPK1 is cleaved by CASP8 (Canis familiaris)
        
        TRADD:TRAF2:RIPK1:FADD [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1 [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)
        
        TRAF2:TRADD:RIPK1(325-671):FADD [cytosol] (Canis familiaris)
        
        TRAF2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MQC7

Gene Names

TRAF2

Reference Genes

BioGPS Gene:480673 TRAF2

ENSEMBL:ENSCAFG00845005186.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845005186.1 TRAF2

KEGG Gene (Canis lupus familiaris):480673 TRAF2

Monarch:480673 TRAF2

NCBI Gene:480673 TRAF2

Reference Transcript

Other Identifiers

480673

Cfa.19495.1.S1_s_at

Cfa.2793.1.S1_at

CfaAffx.29873.1.S1_s_at

GO:0000151

GO:0002376

GO:0002637

GO:0002726

GO:0002947

GO:0003824

GO:0004842

GO:0005164

GO:0005174

GO:0005515

GO:0005737

GO:0005783

GO:0005829

GO:0005886

GO:0007165

GO:0007250

GO:0008270

GO:0008289

GO:0009898

GO:0012501

GO:0012506

GO:0016071

GO:0016740

GO:0019899

GO:0019901

GO:0019903

GO:0023019

GO:0023052

GO:0030163

GO:0030674

GO:0031625

GO:0031996

GO:0032743

GO:0033209

GO:0035631

GO:0036211

GO:0038061

GO:0042802

GO:0042981

GO:0043120

GO:0043123

GO:0043226

GO:0043254

GO:0044877

GO:0045087

GO:0045121

GO:0046328

GO:0046625

GO:0046872

GO:0048255

GO:0051865

GO:0060090

GO:0065003

GO:0070534

GO:0071732

GO:0097057

GO:0097300

GO:0097400

GO:0098542

GO:0140096

GO:1903265

GO:1990604

GO:2001238

Participates

as a member of

as a component of

as an input of

TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 (Canis familiaris)

Other forms of this molecule

TRAF2 [nucleoplasm]

TRAF2 [cytosol]

Inferred From

TRAF2 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_005625131.1, XP_005625129.1, XP_005625130.1

OpenTargets

ENSG00000127191

Ensembl

ENSCAFP00845007298, ENSCAFG00845005186, ENSCAFT00845009283

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