Reactome | ehs-1 [cytosol]

ehs-1 [cytosol]

Stable Identifier

R-CEL-8935900

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

EPS15L1, Q9BIF4

Locations in the PathwayBrowser

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Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ehs-1 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ehs-1 [cytosol] (Caenorhabditis elegans)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ehs-1 [cytosol] (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        ehs-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9BIF4

Gene Names

ehs-1

Reference Genes

BioGPS Gene:173985 ehs-1

CTD Gene:173985 ehs-1

ENSEMBL:WBGene00001224

KEGG:cel:CELE_ZK1248.3 ehs-1

Monarch:173985 ehs-1

NCBI Gene:173985 ehs-1

UCSC:Q9BIF4 ehs-1

Wormbase:WBGene00001224

Wormbase:WBGene00001224 ehs-1

Reference Transcript

RefSeq:NM_001027328.7 ehs-1

Other Identifiers

173985

GO:0005509

GO:0005515

GO:0005737

GO:0005856

GO:0005886

GO:0006897

GO:0007268

GO:0010008

GO:0016192

GO:0016197

GO:0030132

GO:0030424

GO:0030674

GO:0045202

GO:0048488

GO:0060090

GO:0098793

Participates

as a component of

EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)

Other forms of this molecule

phospho-ehs-1 [cytosol]

ehs-1 [plasma membrane]

ehs-1 [cytosol]

Inferred From

EPS15L1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001022499.2

ENSEMBL

WBGene00001224, ZK1248.3a.1, ZK1248.3a.1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:G5EE56	20	SRC-2 [cytosol] (R-CEL-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-CEL-1810408) FYN [cytosol] (R-CEL-200917) LCK [cytosol] (R-CEL-167609) SRC-1 [plasma membrane] (R-CEL-65043) phospho-MyrG-p-Y426-YES1 [plasma membrane] (R-CEL-1810411) phospho-MyrG-p-Y420-FYN-1 [plasma membrane] (R-CEL-9032530) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-CEL-377598) phospho-p-Y420-FYN [cytosol] (R-CEL-391821) LYN [cytosol] (R-CEL-354251) phospho-p-Y419-SRC [cytosol] (R-CEL-377592) FGR [cytosol] (R-CEL-432116) YES1 [cytosol] (R-CEL-373640) HCK [cytosol] (R-CEL-167708) phospho-p-Y397-LYN [plasma membrane] (R-CEL-2454229) phospho-p-Y394-LCK [plasma membrane] (R-CEL-8857940) phospho-p-Y419-SRC-1 [plasma membrane] (R-CEL-112331) MyrG-SRC [plasma membrane] (R-CEL-8876922) LYN [plasma membrane] (R-CEL-197943) phospho-p-S21,Y420-FYN [cytosol] (R-CEL-5218745)	0.553	3

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